Dihydroprehelminthosporol
Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chemistry of Natural Compounds, 2015, 51(2):270-272.
Chemical Constituents of the Fungus Veronaea sp.[Reference:
WebLink]
METHODS AND RESULTS:
A new compound, isoDihydroprehelminthosporol (1), and five known compounds, Dihydroprehelminthosporol (2), 4-(2-hydroxyethyl)phenol (3), anhydrocochlioquinone A (4), isocochlioquinone A (5), and cochlioquinone A (6), were isolated from the fungus Veronaea sp. 1.03621. Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR.
CONCLUSIONS:
These compounds were tested for their cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3, and exhibited different activity.
J Nat Prod. 1988 Sep;51(5):821-8.
Toxins from weed pathogens, I. Phytotoxins from a bipolaris pathogen of johnson grass.[Reference:
WebLink]
METHODS AND RESULTS:
Two strongly phytotoxic metabolites, prehelminthosporol [1] and Dihydroprehelminthosporol [4], have been isolated from culture filtrates of a Bipolaris species pathogenic to Johnson grass. Prehelminthosporol [1] occurs naturally as a mixture of epimers. The isomers have been separated as the corresponding acetyl derivatives, and the stereochemistry at the hemiacetal carbon has been determined by nOe experiments.
CONCLUSIONS:
Four other structurally related sesquiterpenes, helminthosporal acid [6], helminthosporol [8], helminthosporic acid [9], and isosativenediol [10], were also isolated but showed no significant activity.
