Demethylcarolignan E
Demethylcarolignan E is a natural product from Hibiscus taiwanensis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Pharm Biomed Anal.2024, 251:116444.
Front Pharmacol.2023, 14:1244655.
Journal of Natural Remedies2024, 24(3):555¨C575.
J Biochem Mol Toxicol.2022, e23211.
Nutrients.2024, 16(7):965.
Data Science for Genomics2023, 107-128.
Applied Biological Chemistry2021, 64(4)
Pharmaceutics2022, 14(2),376.
Toxicol In Vitro.2019, 59:161-178
Biomol Ther (Seoul).2020, 28(6):542-548.
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Bioorg Med Chem. 2004 May 1;12(9):2193-7.
Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis.[Pubmed:
15080919]
METHODS AND RESULTS:
The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-Demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies.
CONCLUSIONS:
In cytotoxicity evaluation of the isolates, 9,9'-O-feruloyl-(-)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC(50) values of 1.8 and 3.9 microg/mL, respectively.
