Dehydroevodiamine hydrochloride has novel anti-cholinesterase and antiamnesic activities, it inhibits acetylcholinesterase activity in a dose-dependent and non-competitive manner(IC50=37.8 microM); its potent antiamnesic effect is thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement. Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv) can increase the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats, suggest that it selectively increases cerebral blood flow.
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J Nat Prod. 1994 Mar;57(3):387-9.
Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa.[Pubmed: 8201313
METHODS AND RESULTS:
Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined.
These results suggest that the compound selectively increases cerebral blood flow.
Planta Med. 1996 Oct;62(5):405-9.
Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa.[Pubmed: 8923803
To find a new compound with antiamnesic activity, we screened 29 natural products for their abilities to inhibit acetylcholinesterase and reverse scopolamine-induced amnesia.
METHODS AND RESULTS:
Among the plants tested Evodia rutaecarpa Bentham showed a strong inhibitory effect on acetylcholinesterase in vitro and an anti-amnesic effect in vivo. By sequential fractionation of E. rutaecarpa, the active component was finally identified as Dehydroevodiamine hydrochloride (DHED). DHED inhibited acetylcholinesterase activity in a dose-dependent and non-competitive manner. The IC50 value of DHED is 37.8 microM. A single administration of DHED to rats (6.25 mg/kg) significantly reversed the scopolamine-induced memory impairment in a passive avoidance test. The antiamnesic effect of DHED was more potent than that of tacrine which is the only drug for Alzheimer's disease approved by FDA. This potent antiamnesic effect of DHED was thought to be due to the combined effects of acetylcholinesterase inhibition and the known cerebral blood flow enhancement.
These results indicate that DHED has novel anti-cholinesterase and antiamnesic activities and might have therapeutic potential in various disorders including Alzheimer's disease.