Danshenxinkun A
Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system. Oleoyl danshenxinkun A also selectively inhibits rabbit platelet aggregation induced by arachidonic acid.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Liquid Chromatography & Related Technologies, 2019,42:115-121.
Rapidly identify compounds from danshen by using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer and predict its mechanisms of intervening thrombotic diseases.[Reference:
WebLink]
Danshen, having good efficacies of dilating the coronary artery, improving microcirculation and preventing thrombosis, is widely used in clinic to treat various thrombotic diseases in China. This study aimed to identifying and analyzing the chemical constituents of Danshen from different planting areas based on UHPLC-LTQ-Orbitrap MS and comprehensively predicting the potential pharmacological targets and pathways of the main chemical constituents that involve in the treatment of thrombotic diseases by using network pharmacology.
METHODS AND RESULTS:
As a result, we identified 870 single peaks from total ion current and accurately identified 19 compounds from Danshen in this study. Further analysis showed that these compounds had three types of accumulation patterns and contents of most compounds had significant differences in samples from different planting areas. Network pharmacological analysis showed that Tanshinone IIA, Tanshinone IIB, Dehydromiltirone, Cryptotanshinone, Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone might intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system.
CONCLUSIONS:
This study provides a scientific basis for exploring the mechanism of Danshen in treating thrombotic diseases and controlling the quality of Danshen-related preparations.
Journal of Natural Products, 2001, 64(5):648-650.
Two new fatty diterpenoids from Salvia miltiorrhiza.[Reference:
WebLink]
METHODS AND RESULTS:
Two new fatty abietane diterpenoids, oleoyl neocryptotanshinone (1) and oleoyl Danshenxinkun A (2), were isolated as minor components from the roots of Salvia miltiorrhiza. Their structures were established on the basis of spectral evidence.
CONCLUSIONS:
In preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid.
