D-Sorbose
D-Sorbitose has the anti-obesity , anti-hyperglycaemic activities and the effect of enhancing lipid metabolism. D-sorbose have an inhibitory effect on disaccharidase activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nutr Res . 2014 Nov;34(11):961-967.
D-sorbose inhibits disaccharidase activity and demonstrates suppressive action on postprandial blood levels of glucose and insulin in the rat[Pubmed:
25311612]
In an attempt to develop D-Sorbose as a new sweetener that could help in preventing lifestyle-related diseases, we investigated the inhibitory effect of D-Sorbose on disaccharidase activity, using the brush border membrane vesicles of rat small intestines. The inhibitory effect was compared with that of L-sorbose and other rare sugars, and the small intestinal disaccharidases in rats was compared with that of humans as well. In humans and the small intestines of rats, D-Sorbose strongly inhibited sucrase activity and weakly inhibited maltase activity. Inhibition by D-Sorbose of sucrase activity was similar to that of L-arabinose, and the K(i) of D-Sorbose was 7.5 mM. Inhibition by D-Sorbose was very strong in comparison with that of L-sorbose (K(i), 60.8 mM), whereas inhibition of d-tagatose was between that of D-Sorbose and L-sorbose. The inhibitory mode of D-Sorbose for sucrose and maltase was uncompetitive, and that of L-sorbose was competitive. To determine a suppressive effect on postprandial blood levels of glucose and insulin via inhibition of sucrase activity, sucrose solution with or without D-Sorbose was administered to rats. Increments in the blood levels of glucose and insulin were suppressed significantly after administration of sucrose solution with D-Sorbose to rats, in comparison to administration of sucrose solution without D-Sorbose. In contrast, the suppressive effect of L-sorbose on postprandial blood levels of glucose and insulin was very weak. These results suggest that D-Sorbose may have an inhibitory effect on disaccharidase activity and could be used as a sweetener to suppress the postprandial elevation of blood levels of glucose and insulin. The use of D-Sorbose as a sweetener may contribute to the prevention of lifestyle-related diseases, such as type 2 diabetes mellitus.
J Sci Food Agric . 2018 Mar;98(5):2020-2026.
Rare sugars, d-allulose, d-tagatose and d-sorbose, differently modulate lipid metabolism in rats[Pubmed:
28940418]
Background: Rare sugars including d-allulose, d-tagatose, and D-Sorbose are present in limited quantities in nature; some of these rare sugars are now commercially produced using microbial enzymes. Apart from the anti-obesity and anti-hyperglycaemic activities of d-allulose, effects of these sugars on lipid metabolism have not been investigated. Therefore, we aimed to determine if and how d-tagatose and D-Sorbose modulate lipid metabolism in rats. After feeding these rare sugars to rats, parameters on lipid metabolism were determined.
Results: No diet-related effects were observed on body weight and food intake. Hepatic lipogenic enzyme activity was lowered by d-allulose and D-Sorbose but increased by d-tagatose. Faecal fatty acid excretion was non-significantly decreased by d-allulose, but significantly increased by D-Sorbose without affecting faecal steroid excretion. A trend toward reduced adipose tissue weight was observed in groups fed rare sugars. Serum adiponectin levels were decreased by D-Sorbose relative to the control. Gene expression of cholesterol metabolism-related liver proteins tended to be down-regulated by d-allulose and D-Sorbose but not by d-tagatose. In the small intestine, SR-B1 mRNA expression was suppressed by D-Sorbose.
Conclusion: Lipid metabolism in rats varies with rare sugars. Application of rare sugars to functional foods for healthy body weight maintenance requires further studies. © 2017 Society of Chemical Industry.
J Nutr Sci Vitaminol (Tokyo) . 2014;60(4):297-299.
Dietary D-sorbose decreases serum insulin levels in growing Sprague-Dawley rats[Pubmed:
25297620]
D-Sorbose is naturally occurring rare sugar. In this study, we examined the effects of dietary D-Sorbose in rats. Four-week-old male Sprague-Dawley rats were fed either an AIN-93G-based control diet or a 3% D-Sorbose diet for 28 d. Body weight and body fat accumulation were not different between the two diet groups. Dietary supplementation of D-Sorbose lowered the serum insulin level (*p<0.05) significantly compared to the control, although the glucose was not changed. In addition, the relative weight of the cecum increased significantly in the D-Sorbose group (**p<0.01). These findings suggest that intake of D-Sorbose may improve the glucose metabolism by reducing insulin secretion, and D-Sorbose can be used as a food ingredient.
