Cycloart-22-ene-3,25-diol
Cycloart-22-ene-3,25-diol shows tyrosinase inhibitory activity, the IC50 value of 77.5 uM .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chemistry of Natural Compounds, 2014 , 50 (5) :810-3.
Tyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia[Reference:
WebLink]
METHODS AND RESULTS:
The chloroform extract of the aerial parts of E. macrostegia has yielded a new compound, 2-(4-hydroxyphenyl)-ethylhentriacontanoate (1), along with hentriacontan-1-ol (2), lupenone (3), Cycloart-22-ene-3,25-diol (4), 3,3′,4′-tri-O-methylellagic acid (5), cleomiscosin (6), and glucoclioniasterol (stigmast-5-en-3-O-β-glucopyranoside) (7), and from the ethyl acetate extract of aerial parts of the plant isoquercetin (8), quercetin-3-O-α-arabinofuranoside (avicularin) (9), and rutin (10) have been isolated.
CONCLUSIONS:
Compounds 1–10 were tested for their tyrosinase inhibitory activity, and 2 exhibited an IC50 value of 71.4 μM, almost comparable to standard kojic acid (IC50 58.2 μM). Compounds 1–4 also showed good activity with IC50 values of 77.2, 78.6, 71.4, and 77.5 μM, respectively.
