Cycloart-23-ene-3,25-diol
Cycloart-23-ene-3,25-diol has anti-inflammatory activity, it has protective activity against streptozotocin induced toxicity. Cycloart-23-ene-3,25-diol treatment can decrease liver malondialdehyde but increase superoxidase dismutase and reduced glutathione.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Cells.2023, 12(1):168.
Front Microbiol.2024, 15:1429027.
Ulm University Medical Center2020, doi: 10.18725.
Metabolites. 2023, 13(11):1122.
ACS Pharmacol. Transl. Sci.2023, 3c00129.
Int J Mol Sci.2024, 25(6):3390.
J Nat Sc Biol Med2019, 10(2):149-156
Evid Based Complement Alternat Med.2018, 2018:4580627
Biol Pharm Bull.2018, 41(11):1685-1693
Pharmaceuticals.2022, 15(4), 402.
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Afr J Tradit Complement Altern Med. 2014 Apr 3;11(3):124-31.
Antibacterial and anti-biofilm activity of flavonoids and triterpenes isolated from the extracts of Ficus sansibarica Warb. subsp. sansibarica (Moraceae) extracts.[Pubmed:
25371574]
METHODS AND RESULTS:
Three triterpenes and three flavonoids: lupeol acetate (1); Cycloart-23-ene-3,25-diol (2); β-sitosterol (3); 5,7,4'-trihydroxyflavan-3-ol (4); epicatechin (5); and isovitexin (6) were isolated in this study. Antimicrobial activity was observed at 8 mg mL(-1) for Staphylococcus aureus ATCC 29213 with four of the six isolated compounds, with no activity being observed at 1 - 4 mg mL(-1) against Escherichia coli ATCC 25922, E. coli ATCC 35218 and S. aureus ATCC 43300. Epicatechin (5) was found to decrease adhesion of E. coli ATCC 25922 and S. aureus ATCC 29213. Decreased adhesion of S. aureus ATCC 29213 was also observed with 5,7,4'-trihydroxyflavan-3-ol (4) and isovitexin (6).
CONCLUSIONS:
The results of this study provide baseline information on F. sansibarica's potential validity in the treatment of infections associated with Gram-positive microorganisms.
J Nat Prod. 2001 Apr;64(4):518-21.
Cacalolides from Senecio madagascariensis.[Pubmed:
11325239]
METHODS AND RESULTS:
14-Isovaleryloxy-O-methyl-1,2-dehydrocacalol (1) and Cycloart-23-ene-3,25-diol, beta-sitosterol, and stigmasterol, along with five new cacalolides, 1-hydroxy-2-methoxy-1,2,3,4-dehydro-6-dehydroxycacalone (2), 1-hydroxy-2-methoxy-1,2,3,4-dehydrocacalone (3), 1,2-dimethoxy-1,2,3,4-dehydro-6-dehydroxycacalone (4), 1,2-dimethoxy-1,2,3,4-dehydrocacalone (5), and 2-methoxy-O-methyl-1-oxo-2,3-dehydrocacalol (6), were isolated from Senecio madagascariensis collected from Colombia.
CONCLUSIONS:
The structures of the new compounds were determined using one- and two-dimensional NMR techniques. In addition, the structure of 2 was corroborated by derivatizations and single-crystal X-ray diffraction studies.
