Cyclo(Tyr-Phe)
Cyclo-(Phe-Tyr) shows anticoagulant activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Traditional Patent Medicine, 2015,37 (1): 34-9.
Anticoagulant activity of cyclic dipeptides from Sparganii Rhizome[Reference:
WebLink]
To study the in vitro anticoagulant activity of cyclodipeptide( cyclo-( Tyr-Leu),cyclo-( PhePhe) and cyclo-( Phe-Tyr)) isolated from Sparganium stoloniferum Buch.-Ham.
METHODS AND RESULTS:
The special kits were used to measure anticoagulant activity with platelet poor plasma collected from abdominal aorta of male SD rats,including prothrombin time( PT),activated partial thromboplastin time( APTT) and thrombin time( TT).PT,APTT,TT were prolonged by the addition of cyclo-( Tyr-Leu),cyclo-( Phe-Phe) and Cyclo(Tyr-Phe). The former two presented no dose-effect relationship but the latter did.
CONCLUSIONS:
Of three cyclodipeptides from S. stoloniferum,all the three show anticoagulant activities with cyclo-( Phe-Tyr) being by far the most effective.
