(-)-Corlumine

(-)-Corlumine
Product Name (-)-Corlumine
CAS No.: 79082-64-7
Catalog No.: CFN96340
Molecular Formula: C21H21NO6
Molecular Weight: 383.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: GABA Receptor
Source: The herbs of Fumaria parviflora.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Corlumine exhibits spasmolytic and GABA antagonist activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Sep Sci.2021, 44(22):4064-4081.
  • Medicina (Kaunas).2020, 56(12):685.
  • J Ethnopharmacol.2022, 291:115159.
  • Neurochem Res.2021, s11064-021-03449-0
  • Plants (Basel).2021, 10(7):1376.
  • J Agric Food Chem.2018, 66(1):351-358
  • Indian J Pharm Sci.2024, 86(2):736-741.
  • J Colloid Interface Sci.2024, 662:760-773.
  • Nat Commun.2021, 12(1):681.
  • Int J Mol Sci.2023, 24(23):17118.
  • (-)-Bicuculline methochloride

    Catalog No: CFN92860
    CAS No: 53552-05-9
    Price: Inquiry(manager@chemfaces.com)
    Hypecorinine

    Catalog No: CFN92333
    CAS No: 41787-57-9
    Price: Inquiry(manager@chemfaces.com)
    Isohyperectine

    Catalog No: CFN92448
    CAS No: 170384-75-5
    Price: Inquiry(manager@chemfaces.com)
    Hyperectine

    Catalog No: CFN92449
    CAS No: 94656-46-9
    Price: Inquiry(manager@chemfaces.com)
    Colchiceine

    Catalog No: CFN91828
    CAS No: 477-27-0
    Price: Inquiry(manager@chemfaces.com)
    Colchicine

    Catalog No: CFN99514
    CAS No: 64-86-8
    Price: $40/20mg
    N-Methylcolchicine

    Catalog No: CFN91817
    CAS No: 7336-40-5
    Price: Inquiry(manager@chemfaces.com)
    Thiocolchicine

    Catalog No: CFN91554
    CAS No: 2730-71-4
    Price: Inquiry(manager@chemfaces.com)
    Thiocolchicoside

    Catalog No: CFN91553
    CAS No: 602-41-5
    Price: Inquiry(manager@chemfaces.com)
    (-)-Corlumine

    Catalog No: CFN96340
    CAS No: 79082-64-7
    Price: Inquiry(manager@chemfaces.com)
    Journal of Natural Products,2004,44(4):475-7.
    (-)-Corlumine, A New Phthalideisoquinoline Alkaloid From Fumaria parviflora[Reference: WebLink]

    METHODS AND RESULTS:
    Fumaria parviflora Lam. (Fumariaceae) has yielded the new phthalideisoquinoline alkaloid (-)-Corlumine (2) previously known only in its dextrorotatory form. Two known alkaloids not previously detected in F. parviflora are (+)-adlumidine (1) and (-)-cheilanthifoline (3).
    CONCLUSIONS:
    Phthalideisoquinoline alkaloids as isolated from plants show no pronounced stereochemical preference either at C-1 or at C-9. Most protoberberine alkaloids, however, possess the S- chirality at C-14.
    Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:470-80.
    Quantum chemical and experimental studies on the structure and vibrational spectra of an alkaloid--Corlumine.[Pubmed: 24080578 ]

    METHODS AND RESULTS:
    The study concentrates on an important natural product, phthalide isoquinoline alkaloid Corlumine (COR) [(6R)-6-[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl] furo [3,4-e]-1,3-benzodioxol-8(6H)-one] well known to exhibit spasmolytic and GABA antagonist activity. It was fully characterized by a variety of experimental methods including vibrational spectroscopy (IR and Raman), thermal analysis (DSC), UV and SEM. For a better interpretation and analysis of the results quantum chemical calculations employing DFT were also performed. TD-DFT was employed to elucidate electronic properties for both gaseous and solvent environment using IEF-PCM model. Graphical representation of HOMO and LUMO would provide a valuable insight into the nature of reactivity and some of the structural and physical properties of the title molecule.
    CONCLUSIONS:
    The structure-activity relationship have been interpreted by mapping electrostatic potential surface (MEP), which is valuable information for the quality control of medicines and drug-receptor interactions. Stability of the molecule arising from hyper conjugative interactions, charge delocalisation has been analyzed using natural bond orbital (NBO) analysis. Computation of thermodynamical properties would help to have a deep insight into the molecule for further applications.
    Pueroside B

    Catalog No: CFN95141
    CAS No: 100692-54-4
    Price: $288/10mg
    Atractylochromene

    Catalog No: CFN95162
    CAS No: 203443-33-8
    Price: $318/10mg
    19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene

    Catalog No: CFN95217
    CAS No: 1011714-20-7
    Price: $318/5mg
    11-Oxomogroside IIA2

    Catalog No: CFN95305
    CAS No: 2170761-37-0
    Price: $368/5mg
    Methyl 2-hydroxy-3,4-dimethoxybenzoate

    Catalog No: CFN95383
    CAS No: 6395-23-9
    Price: $268/5mg
    Dehydrodicatechin A

    Catalog No: CFN95451
    CAS No: 36048-23-4
    Price: $318/5mg
    Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose

    Catalog No: CFN95462
    CAS No: 1825287-22-6
    Price: $318/10mg
    Bayin

    Catalog No: CFN95539
    CAS No: 3681-96-7
    Price: $318/5mg
    Oblongaroside B

    Catalog No: CFN95543
    CAS No: 1000889-11-1
    Price: $318/10mg
    1-Phenylethyl beta-D-glucoside

    Catalog No: CFN95574
    CAS No: 93199-03-2
    Price: $318/5mg