(-)-Corlumine
Corlumine exhibits spasmolytic and GABA antagonist activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Natural Products,2004,44(4):475-7.
(-)-Corlumine, A New Phthalideisoquinoline Alkaloid From Fumaria parviflora[Reference:
WebLink]
METHODS AND RESULTS:
Fumaria parviflora Lam. (Fumariaceae) has yielded the new phthalideisoquinoline alkaloid (-)-Corlumine (2) previously known only in its dextrorotatory form. Two known alkaloids not previously detected in F. parviflora are (+)-adlumidine (1) and (-)-cheilanthifoline (3).
CONCLUSIONS:
Phthalideisoquinoline alkaloids as isolated from plants show no pronounced stereochemical preference either at C-1 or at C-9. Most protoberberine alkaloids, however, possess the S- chirality at C-14.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:470-80.
Quantum chemical and experimental studies on the structure and vibrational spectra of an alkaloid--Corlumine.[Pubmed:
24080578 ]
METHODS AND RESULTS:
The study concentrates on an important natural product, phthalide isoquinoline alkaloid Corlumine (COR) [(6R)-6-[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl] furo [3,4-e]-1,3-benzodioxol-8(6H)-one] well known to exhibit spasmolytic and GABA antagonist activity. It was fully characterized by a variety of experimental methods including vibrational spectroscopy (IR and Raman), thermal analysis (DSC), UV and SEM. For a better interpretation and analysis of the results quantum chemical calculations employing DFT were also performed. TD-DFT was employed to elucidate electronic properties for both gaseous and solvent environment using IEF-PCM model. Graphical representation of HOMO and LUMO would provide a valuable insight into the nature of reactivity and some of the structural and physical properties of the title molecule.
CONCLUSIONS:
The structure-activity relationship have been interpreted by mapping electrostatic potential surface (MEP), which is valuable information for the quality control of medicines and drug-receptor interactions. Stability of the molecule arising from hyper conjugative interactions, charge delocalisation has been analyzed using natural bond orbital (NBO) analysis. Computation of thermodynamical properties would help to have a deep insight into the molecule for further applications.
