Boeravinone B

Boeravinone B
Product Name Boeravinone B
CAS No.: 114567-34-9
Catalog No.: CFN96206
Molecular Formula: C17H12O6
Molecular Weight: 312.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: Antifection | COX
Source: The roots of Boerhaavia coccinea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $413/5mg
Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exhibits significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Asm Microbe. 2017.
    Boeravinone B, a Natural Rotenoid from Boerhavia diffusa as Novel Inhibitor of MdeA Efflux Pump of Staphylococcus aureus[Reference: WebLink]
    Role of Boeravinone B, a natural rotenoid isolated from Boerhavea diffusa, as a novel MdeA efflux inhibitor. Additionally its impact on biofilm inhibition and in vivo efficacy as topical agent is elucidated.
    METHODS AND RESULTS:
    Combination of Boeravinone B with mupirocin was evaluated against Staphylococcus aureus Mupr-1(MdeA over expressing) a laboratory generated mutant from S. aureus ATCC29213 using microdilution checkerboard. Time kill kinetics and mutation prevention concentration of mupirocin in combination were investigated. Mechanism of action of Boeravinone B was confirmed using ethidium bromide accumulation and efflux assay. Comparative enhancement in accumulation and efflux inhibition of ethidium bromide in presence of Boeravinone B using wild type and mutant (Mupr-1) strains indicates efflux as mechanism of resistance. A combination of 0.5% Boeravinone B with 2% mupirocin exhibited better efficacy resulting in clearance of infection in three days treatment as against 2% mupirocin which heals in 5 days when compared for CFU reduction.
    CONCLUSIONS:
    Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus. From these studies it is clear that Boeravinone B may be used in combination with mupirocin for further development.
    Journal of Natural Products, 2013 , 76 (8) :1393-8.
    Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.[Pubmed: 23914900]

    METHODS AND RESULTS:
    Five new (2, 3, 5, 7, and 9) and four known rotenoids (1, 4, 6, and 8) were isolated from a methanol extract of Boerhaavia diffusa roots. The structures of the new rotenoids were elucidated by spectroscopic data interpretation. The 70% ethanol extract, a rotenoid-rich fraction, and all isolated rotenoids were evaluated for their COX-1 and COX-2 inhibitory activities.
    CONCLUSIONS:
    Among the rotenoids tested, compound 7 showed the most potent COX-1 and COX-2 inhibition, with IC₅₀ values of 21.7 ± 0.5 and 25.5 ± 0.6 μM, respectively. Boeravinone B (6) exhibited significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model.
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