11-Hydroxytephrosin

11-Hydroxytephrosin
Product Name 11-Hydroxytephrosin
CAS No.: 72458-85-6
Catalog No.: CFN97996
Molecular Formula: C23H22O8
Molecular Weight: 426.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: NF-kB | TNF-α
Source: The herbs of Derris robusta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
11-Hydroxytephrosin inhibits NF-kappaB activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • J of Food Quality2020, 8851285.
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  • Sci Rep.2020, 10:4495(2020)
  • Applied Biological Chemistry2022, 65(12)
  • LWT-Food Science and Technology2017, 75:488-496
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  • Anal Bioanal Chem. 2025, 417(17):3879-3892.
  • J Sci Food Agric.2018, 98(3):1153-1161
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    J Nat Prod. 2008 Oct;71(10):1696-700.
    Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.[Pubmed: 18841906]
    NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation.
    METHODS AND RESULTS:
    Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods.
    CONCLUSIONS:
    All compounds inhibited NF-kappaB activity, and tephrosin (1), 11-Hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 microM, respectively, in TNF-alpha-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-kappaB/DNA binding activity and suppressed the expression of NF-kappaB target genes.
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