Benzaldehyden

J Microbiol. 2015 Feb;53(2):127-33.

Benzaldehyde as an insecticidal, antimicrobial, and antioxidant compound produced by Photorhabdus temperata M1021.[Pubmed: 25626368 ]

METHODS AND RESULTS:
The analysis of (1)H and (13)C NMR spectra revealed the identity of pure compound as "Benzaldehyde". The Benzaldehyde showed insecticidal activity against G. mellonella in a dose-dependent manner and 100% insect mortality was observed at 108 h after injection of 8 mM Benzaldehyde. In a PO inhibition assay, 4, 6, and 8 mM concentrations of Benzaldehyde were found to inhibit PO activity about 15%, 42%, and 80% respectively. In addition, nodule formation was significantly (P < 0.05) inhibited by 4, 6, and 8 mM of Benzaldehyde as compare to control. Moreover, Benzaldehyde was found to have great antioxidant activity and maximum antioxidant activity was 52.9% at 8 mM Benzaldehyde as compare to control. Antimicrobial activity was assessed by MIC values ranged from 6 mM 10 mM for bacterial strains and 8 mM to 10 mM for fungal strains.
CONCLUSIONS:
The results suggest that Benzaldehyde could be applicable for developing novel insecticide for agriculture use.

Int Immunopharmacol. 2014 Oct;22(2):444-50.

Benzaldehyde suppresses murine allergic asthma and rhinitis.[Pubmed: 25107441]

METHODS AND RESULTS:
To evaluate the antiallergic effects of oral Benzaldehyde in a murine model of allergic asthma and rhinitis, we divided 20 female BALB/c mice aged 8-10 weeks into nonallergic (intraperitoneally sensitized and intranasally challenged to normal saline), allergic (intraperitoneally sensitized and intranasally challenged to ovalbumin), and 200- and 400-mg/kg Benzaldehyde (allergic but treated) groups. The number of nose-scratching events in 10 min, levels of total and ovalbumin-specific IgE in serum, differential counts of inflammatory cells in bronchoalveolar lavage (BAL) fluid, titers of Th2 cytokines (IL-4, IL-5, IL-13) in BAL fluid, histopathologic findings of lung and nasal tissues, and expressions of proteins involved in apoptosis (Bcl-2, Bax, caspase-3), inflammation (COX-2), antioxidation (extracellular SOD, HO-1), and hypoxia (HIF-1α, VEGF) in lung tissue were evaluated. The treated mice had significantly fewer nose-scratching events, less inflammatory cell infiltration in lung and nasal tissues, and lower HIF-1α and VEGF expressions in lung tissue than the allergic group. The number of eosinophils and neutrophils and Th2 cytokine titers in BAL fluid significantly decreased after the treatment (P<0.05).
CONCLUSIONS:
These results imply that oral Benzaldehyde exerts antiallergic effects in murine allergic asthma and rhinitis, possibly through inhibition of HIF-1α and VEGF.