Alizarin 2-methyl ether
Alizarin 2-methyl ether enhances adipocyte differentiation by up to 131%, it could be beneficial in the treatment of diabetes.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nat Prod Res. 2012;26(18):1750-4.
Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells.[Pubmed:
22008000]
To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining.
METHODS AND RESULTS:
Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), Alizarin 2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, Alizarin 2-methyl ether (2) showed the strongest enhancing activity, followed by rubiadin-1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 µM, Alizarin 2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells).
CONCLUSIONS:
Thus, these compounds could be beneficial in the treatment of diabetes.
Phytochemistry, 1986 , 25 (5) :1123-6.
Anthraquinones in callus cultures of Cinchona pubescens[Reference:
WebLink]
METHODS AND RESULTS:
From callus cultures of Cinchona pubescens seven known anthraquinones, Alizarin 2-methyl ether, anthragallol-1,2-dimethylether, purpurin, purpurin-1-methylether, 1-hydroxy-2-hydroxymethylanthraquinone, 2-hydroxy-1,3,4-trimethoxyanthraquinone and 2,5-(or 3,5-)dihydroxy-1,3,4-(or -1,2,4-)trimethoxyanthraquinone, and five new anthraquinones, 2-hydroxy-1,3,4,6-(or -1,3,4,7-)tetramethoxyanthraquinone, 1,6-(or 1,7-)dihydroxy-2-methylanthraquinone, 5-hydroxy-purpurin-1-methylether, 4,6-(or 4,7)-dihydroxy-2,7-(or -2,6-)dimethoxyanthraquinone and 6,7-dihydroxy-1-methoxy-2-methylanthraquinone have been isolated.
