Albaspidin AP
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inhibitors, and FAS is emerging as a potential therapeutic target to treat cancer and obesity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Toxicol Rep.2021, 8:1131-1142.
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《Journal of Tianjin Medical University》 2007-02
Studies on active constituents in rhizome of Dryopteris crassirhizoma[Reference:
WebLink]
To study the acylphloroglucinols of the Dryopteris Crassirhizoma Nakai.
METHODS AND RESULTS:
The column chromatography of buffered SiO2 and sephadex were used to isolate those constituents which were identified by chemical knowledge and spectroscopic methods. Nine acylphloroglucinol derivatives were obtained and were identified ,the first three compounds of them:albaspidin AA(Ⅰ),Albaspidin AP(Ⅱ) and albasspidin PP(Ⅲ).
CONCLUSIONS:
The compoundsⅡ,Ⅲ are first obtained as crystals from natural plants and are first found from Dryopteris Crassirhizoma. 1H-NMR and 13C-NMR data of compoundⅡ and compound Ⅲ, and 13C-NMR data of compoundⅠ are first reported. On the basis of variety of 2DNMR experiments, NMR data of the three compound are well assigned.
