(+)-Afzelechin

(+)-Afzelechin
Product Name (+)-Afzelechin
CAS No.: 2545-00-8
Catalog No.: CFN98280
Molecular Formula: C15H14O5
Molecular Weight: 274.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Celastrus orbiculatus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
(+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM; it also shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate.(+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Nat Med.2017, 71(2):457-462
  • Sci Rep.2019, 9(1):4646
  • Exp Parasitol.2018, 194:67-78
  • Research Square2021, March 3rd.
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Antioxidants.2022, 11(3):592.
  • Antioxidants (Basel).2021, 10(8):1300.
  • Front Pharmacol.2019, 10:1226
  • FASEB J.2019, 33(2):2026-2036
  • Int J Mol Sci.2022, 23(21):13112.
  • 5,7,4'-Tri-O-methylcatechin

    Catalog No: CFN96042
    CAS No: 105330-59-4
    Price: Inquiry(manager@chemfaces.com)
    (+)-Gallocatechin

    Catalog No: CFN99138
    CAS No: 970-73-0
    Price: $138/20mg
    Afzelechin 3-O-xyloside

    Catalog No: CFN89499
    CAS No: 512781-45-2
    Price: Inquiry(manager@chemfaces.com)
    3,4,4',7-Tetrahydroxyflavan

    Catalog No: CFN98617
    CAS No: 38412-82-7
    Price: Inquiry(manager@chemfaces.com)
    Catechin

    Catalog No: CFN99646
    CAS No: 154-23-4
    Price: $30/20mg
    (+)-Catechin hydrate

    Catalog No: CFN99568
    CAS No: 7295-85-4
    Price: $70/20mg
    Catechin pentaacetate

    Catalog No: CFN99682
    CAS No: 16198-01-9
    Price: Inquiry(manager@chemfaces.com)
    Catechin 7-xyloside

    Catalog No: CFN98665
    CAS No: 42830-48-8
    Price: Inquiry(manager@chemfaces.com)
    Catechin 7-O-beta-D-glucopyranoside

    Catalog No: CFN95524
    CAS No: 65597-47-9
    Price: $338/20mg
    Catechin 7,3'-di-O-beta-D-glucopyranoside

    Catalog No: CFN95717
    CAS No: 105330-53-8
    Price: $413/5mg
    Phytochemistry. 2008 Jan;69(2):451-6.
    Antioxidant aryl-prenylcoumarin, flavan-3-ols and flavonoids from Eysenhardtia subcoriacea.[Pubmed: 17892888]

    METHODS AND RESULTS:
    Antioxidant activity (AOA) assay-guided chemical analysis, using a rat pancreas homogenate model, of aerial parts from Eysenhardtia subcoriacea, led to isolation of the new compound subcoriacin (3-(2'-hydroxy-4',5'-methylendioxyphenyl)-6-(3''-hydroxymethyl-4''-hydroxybut-2''-enyl)-7-hydroxycoumarin) together with the known substances: (+)-catechin, (-)-epicatechin, (+)-Afzelechin, eriodictyol, (+)-catechin 3-O-beta-D-galactopyranoside and quercetin 3-O-beta-D-galactopyranoside as bioactive constituents. The structure of the compound was determined from 1D and 2D NMR spectroscopic analyses. Additional known constituents were characterized.
    CONCLUSIONS:
    The bioactive compounds showed also moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH). In addition, subcoriacin, (+)-catechin, (-)-epicatechin and (+)-Afzelechin improved the reduced glutathione levels in rat pancreatic homogenate.
    Arch Pharm Res. 2005 Jul;28(7):804-9.
    Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis.[Pubmed: 16114495]

    METHODS AND RESULTS:
    The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-Afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 microM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 microM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 microM and 23.7 microM, respectively.
    CONCLUSIONS:
    These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.
    J Oleo Sci. 2008;57(8):431-5.
    Alpha-glucosidase inhibitor from Bergenia ligulata.[Pubmed: 18622126]
    Inhibitory compound of alpha-glucosidase activity, (+)-Afzelechin (1), was isolated from rhizomes of Bergenia ligulata.
    METHODS AND RESULTS:
    The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-Afzelechin tetraacetate (2), (+)-5,7,4'-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4'-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.
    Lappaol A

    Catalog No: CFN95067
    CAS No: 62333-08-8
    Price: $333/10mg
    Polygalasaponin XXXV

    Catalog No: CFN95176
    CAS No: 184479-28-5
    Price: $463/5mg
    Pterodonoic acid

    Catalog No: CFN95183
    CAS No: 62458-42-8
    Price: $413/5mg
    Bergaptol-beta-glucopyranoside

    Catalog No: CFN95186
    CAS No: 131623-13-7
    Price: $318/10mg
    N-Methylcorydalmine

    Catalog No: CFN95204
    CAS No: 81010-29-9
    Price: $398/5mg
    Solafuranone

    Catalog No: CFN95312
    CAS No: 367965-50-2
    Price: $318/5mg
    ZP-amide C

    Catalog No: CFN95362
    CAS No: 412316-38-2
    Price: $413/5mg
    New compound 13

    Catalog No: CFN95374
    CAS No: N/A
    Price: $318/5mg
    8-epi-Confertin

    Catalog No: CFN95509
    CAS No: 110115-60-1
    Price: $318/5mg
    Yakuchinone A

    Catalog No: CFN95555
    CAS No: 78954-23-1
    Price: $318/10mg