Actinidic acid
Actinidic acid is a triterpene phytoalexin from unripe kiwi fruit.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Molecules.2020, 25(9):2111.
Biosci Biotechnol Biochem.2020, 84(3):621-632
Chemistry of Vegetable Raw Materials2019, 3:119-127
Eur J Pharmacol.2021, 906:174220.
JMSACL2023, 09.002
J Food Sci.2021, 86(9):3810-3823.
Metabolites.2019, 9(11):E271
Food Res Int.2021, 148:110607.
Food Funct.2022, 13(13):6923-6933.
Cardiovasc Toxicol.2021, 21(11):947-963.
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Arch Pharm Res. 2008 May;31(5):666-70.
A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta.[Pubmed:
18481026]
METHODS AND RESULTS:
A new coumaroyl triterpene, 3-O-trans-p-coumaroyl Actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL).
CONCLUSIONS:
Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC(50) of 14.95 microM, followed by ursolic acid (2, IC(50) = 15.83 microM). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC(50) values ranging from 20.42 to 76.45 microM.
Biosci Biotechnol Biochem. 2001 Feb;65(2):480-3.
Actinidic acid, a new triterpene phytoalexin from unripe kiwi fruit.[Pubmed:
11302196]
METHODS AND RESULTS:
Seven phytoalexins (1-7), including a new compound, were isolated from the peel of unripe kiwi fruit (Actinidia deliciosa cv. Golden King) that had been wounded and inoculated with Colletotrichum musae. The new phytoalexin (1) was identified as 2alpha,3beta,23-trihydroxy-12,20(30)-ursadien-28-oic acid, and named Actinidic acid.
CONCLUSIONS:
Phytoalexins 2-6 are known triterpenes but have not previously been described as phytoalexins. Phytoalexin 7 is the same triterpene as the phytoalexin of nectarine fruit.
