9-Dihydro-13-acetylbaccatin III
9-Dihydro-13-acetylbaccatin III shows cytotoxicity against the MCF7 cell line and drug resistant cell line MCF7-ADR.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Bioorg Med Chem. 2003 Apr 3;11(7):1551-6.
Semi-synthesis of an O-glycosylated docetaxel analogue.[Pubmed:
12628678]
A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-Dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis.
METHODS AND RESULTS:
It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
Bioorg Med Chem. 2000 Jun;8(6):1269-80.
Taxus canadensis abundant taxane: conversion to paclitaxel and rearrangements.[Pubmed:
10896107]
An efficient conversion of Taxus canadensis abundant taxane, 9-Dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes derived from skeletal rearrangements originating from oxidation reduction reactions of the Canadian yew major taxane, are reported.
