7-Xylosyl-10-deacetylbaccatin III
7-Xylosyl-10-deacetylbaccatin III is a natural product from Taxus brevifolia.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J of Applied Biological Chem.2020, 63(2):147-152
United States Patent Application2020, 20200038363
Appl. Sci.2020, 10(8),2804
Molecules.2020, 25(21):5091.
Oncol Rep.2021, 46(2):166.
Mol Med Rep.2022, 26(4):299.
Eur J Pharmacol.2021, 906:174220.
Nat Prod Sci.2018, 24(2):109-114
Nutrients.2022, 14(16):3393.
Nat Prod Communications2018, 10.1177
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Biotechnology & Applied Biochemistry, 1997, 26(3):153-158.
Enzymic hydrolysis of 7-xylosyltaxanes by xylosidase from Moraxella sp.[Reference:
WebLink]
The production of large quantities of paclitaxel for use as an anticancer treatment has been a difficult problem because of the low concentration of the compound in yew trees (Taxus sp.) and its occurrence as part of a mixture of other taxanes. 7-Xylosyltaxanes are major components of the mixture found in the bark of the Pacific yew (Taxus brevifolia).
METHODS AND RESULTS:
A bacterial strain isolated from soil and identified as a Moraxella sp. was able to remove the xylosyl group from 7-xylosylpaclitaxel 7-xylosyl-10-deacetylpaclitaxel, 7-xylosylbaccatin III and 7-Xylosyl-10-deacetylbaccatin III, thereby making the xylosyltaxanes available as sources of 10-deacetylbaccatin III for semisynthesis of paclitaxel.
CONCLUSIONS:
The activity was located in both the soluble and particulate fractions of the cell.
