6-Hydroxy-5,6-dehydrosugiol
6-Hydroxy-5,6-dehydrosugiol is a potent androgen receptor antagonist in prostate cancer cells, it has potential for use in chemoprevention and chemotherapy of prostate cancers.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cancer Res. 2008 Aug 15;68(16):6634-42.
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.[Pubmed:
18701487 ]
Androgen receptor (AR) is the main therapeutic target for treatment of metastatic prostate cancers (PCa). As recurrent tumors restore AR activity independent of hormones, new therapies that abolish AR activity have been sought to prevent or delay the emergence of ablation-resistant disease.
METHODS AND RESULTS:
Here, we report that a novel abietane diterpene, 6-Hydroxy-5,6-dehydrosugiol (HDHS), isolated from the stem bark of Cryptomeria japonica, was a potent AR antagonist in PCa cells. HDHS treatment of androgen-dependent LNCaP and androgen-responsive 22Rv1 cells induced apoptosis as shown by nucleosome release, activation of caspase-3 and caspase-7, and cleavage of poly(ADP-ribose) polymerase accompanied with concomitant up-regulation of tumor suppressor p53. HDHS also decreased the protein expression of cyclins (D1 and E), cyclin-dependent kinases (CDK2, CDK4, and CDK6), and retinoblastoma phosphorylation in PCa cells, which suggest cell cycle arrest in the G(1) phase. Oral administration of HDHS at 0.5 and 2.5 mg/kg once daily for 24 days to 22Rv1 PCa xenografted mice suppressed tumor growth by 22% and 39%, respectively, in association with decreased proliferation and increased apoptosis in tumor cells, which further correlated with increased levels of HDHS in plasma and tumors.
CONCLUSIONS:
Overall, our data suggest that HDHS has potential for use in chemoprevention and chemotherapy of PCa.
Holzforschung, 2002 , 56 (5) :487-492。
Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata[Reference:
WebLink]
Nine abietane-type diterpenes were isolated from the heartwood of Taiwania cryptomerioides and their structures identified by spectral analyses.
METHODS AND RESULTS:
Among these nine compounds, six diterpenes were isolated for the first time from T. cryptomerioides, including 6,7-dehydroferruginol, 6α-hydroxysugiol, 5,6-dehydro-6-hydroxysugiol(6-Hydroxy-5,6-dehydrosugiol), 11-hydroxyferruginol, secoabietane dialdehyde and isohinokiol. We suggest that abietane-type diterpenes are the dominant diterpenes in the heartwood of T. cryptomerioides. A possible biosynthesis pathway is proposed. In addition, a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was performed to evaluate the antioxidant activity of these diterpenes.
CONCLUSIONS:
This study demonstrates that ferruginol exhibits the strongest antioxidant activity among the diterpenes isolated from T. cryptomerioides heartwood.
