6-Deoxyisojacareubin

6-Deoxyisojacareubin
Product Name 6-Deoxyisojacareubin
CAS No.: 26486-92-0
Catalog No.: CFN89446
Molecular Formula: C18H14O5
Molecular Weight: 310.30 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Powder
Targets: PKC | Antifection
Source: The stem-barks of Garcinia nervosa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibition of protein kinase C (PKC).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Arch Pharm (Weinheim). 2013 Apr;346(4):314-20.
    Efficient total synthesis and biological activities of 6-deoxyisojacareubin.[Pubmed: 23519477 ]

    METHODS AND RESULTS:
    6-Deoxyisojacareubin was directly synthesized in a six-step route with an overall yield of about 20%. In this route, the excellent site selectivity of this Claisen rearrangement-cyclization reaction cascade was achieved by inserting a bulky p-tosyl group into the free 1-OH, and in the last step, some efficient demethylation methods were explored. Furthermore, all synthesized intermediates including 6-Deoxyisojacareubin were evaluated for their inhibitory activity against the QGY-7703 cell line.
    CONCLUSIONS:
    Of these, compound 1 and 6-Deoxyisojacareubin showed moderate activities with IC50 values of 39.61 and 9.65 μM, respectively, when compared to the positive control 5-fluorouracil with an IC50 value of 11.24 μM. Further investigation using non-radioactive detection of protein kinase C (PKC) suggested that these two compounds possessed potency in the inhibition of PKC.
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