5-Methoxy-7-hydroxycoumarin
7-Hydroxy-5-methoxycoumarin, has been found to be a moderate inhibitor for aldehyde oxidase, a molybdo-flavoenzymes, it inhibits the release of superoxide anion more efficiently than hydrogen peroxide or substrate oxidation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Comparative Effects of Scopoletin and Menadione on Aldehyde Oxidase Activity of Guinea Pig Liver[Reference:
WebLink]
Scopoletin, 7-hydroxy-5-methoxycoumarin(5-Methoxy-7-hydroxycoumarin ), has been found to be a moderate inhibitor for aldehyde oxidase, a molybdo-flavoenzymes.
It inhibits the release of superoxide anion more efficiently than hydrogen peroxide or substrate oxidation.
METHODS AND RESULTS:
Statistically, the inhibition of three-specific aldehyde oxidase substrates was significant (p<0.005) in the presence of 100 uM Scopoletin. A progressive and non-competitive inhibition has been observed with inhibitor constant (Ki) value of 57.2 uM using indole-3-aldehyde and oxygen as a substrate and electron acceptor, respectively. A specific site for interaction between Scopoletin and aldehyde oxidase has been proposed and its effect on the reactive oxygen species production has been discussed.
CONCLUSIONS:
The effect of Scopoletin on aldehyde oxidase activity has been compared with that of traditional and specific inhibitors, such as menadione.
