4-Hydroxyisophthalic acid
4-Hydroxyisophthalic acid has analgesic and antipyretic activities.It could be a promising natural antioxidant and a neuroprotective molecule targeting oxidative stress-mediated mitochondrial dysfunction with therapeutic potential for neurodegenerative disorders.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Neurotoxicology, 2018,46:160-169.
Neuroprotective action of 4-Hydroxyisophthalic acid against paraquat-induced motor impairment involves amelioration of mitochondrial damage and neurodegeneration in Drosophila.[Reference:
WebLink]
Neurodegenerative disorders including Parkinson’s disease (PD) are believed to be caused by oxidative stress and mitochondrial dysfunction. Exposure to environmental agents such as pesticides has been implicated in the etiology of sporadic PD. Paraquat (PQ), a widely used herbicide, induces PD symptoms in laboratory animals including Drosophila. PQ acts as a free radical generator and induces oxidative damage, which is implicated in neuronal cell death. Drosophila model of PQ-induced PD offers a convenient tool for mechanistic studies and, to assess the neuroprotective potential of natural antioxidants.
METHODS AND RESULTS:
We have investigated the neuroprotective potential of 4-Hydroxyisophthalic acid (DHA-I), a novel bioactive molecule from the roots of Decalepis hamiltonii, against PQ-induced locomotor impairment and neurodegeneration in Drosophila melanogaster. Our study shows that PQ treatment results in movement disorder associated with oxidative stress-mediated mitochondrial damage and neurodegeneration in the brain as evident by ultrastructural observations. Treatment with DHA-I markedly attenuated locomotor deficits, oxidative stress, mitochondrial damage, and neurodegenerative changes induced by PQ in Drosophila.
CONCLUSIONS:
Our results show that DHA-I could be a promising natural antioxidant and a neuroprotective molecule targeting oxidative stress-mediated mitochondrial dysfunction with therapeutic potential for neurodegenerative disorders.
Nature, 1955, 175(4448):206.
Analgesic and Antipyretic Activities of 4-Hydroxyisophthalic Acid.[Reference:
WebLink]
Analgesic and Antipyretic Activities of 4-Hydroxyisophthalic acid
METHODS AND RESULTS:
4-Hydroxyisophthalic acid is a by-product of the manufacture of salicylic acid by the Kolbe-Schmitt reaction and has been found to be a major constituent of the `brown dust' residues from the sublimation process for the purification of salicylic acid1. Analysis of a typical sample of `brown dust' showed it to contain 10 per cent of salicylic, 82 per cent of 4-hydroxyisophthalic and 3 per cent of 2-hydroxyisophthalic acids, together with some inorganic material. From this source there is thus potentially available a considerable quantity of 4-Hydroxyisophthalic acid, the chemistry of which is being investigated as part of a research programme on the Kolbe-Schmitt reaction at the Chemical Research Laboratory2. From a consideration of its structural similarity to salicylic acid, it was suggested at the Chemical Research Laboratory that 4-Hydroxyisophthalic acid might also possess similar pharmacological properties.
CONCLUSIONS:
Accordingly, in February 1954, a pharmacological investigation was initiated at Ware and, since the findings were favourable, biochemical studies were also undertaken.
