4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone

Structure
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone
Summary
Product Name 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone
CAS No.: 151752-08-8
Catalog No.: CFN91700
Molecular Formula: C17H18O5
Molecular Weight: 302.3 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The herbs of Dracaena cochinchinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $238/5mg
Description
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity.
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Storage
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Product Use Citation
  • Fitoterapia.2024, 177:106138.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • American Association for Anatomy2020, doi: 10.1002.
  • Plant J.2017, 90(3):535-546
  • Plants (Basel).2021, 10(11):2525.
  • Nutrients.2024, 16(7):985.
  • Front Pharmacol.2016, 7:460
  • Int Immunopharmacol.2020, 90:107268.
  • Cell Chem Biol.2019, 26(1):27-34
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    In vitro
    Planta Med . 2002 Sep;68(9):841-843.
    Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri[Pubmed: 12357401]
    Fom the stem wood of Dracaena loureiri, a new homoisoflavanone named loureiriol (1) and eight known flavonoid and stilbenoid derivatives, including 5,7-dihydroxy-3-(4-hydroxybenzyl)-4-chromanone (2), 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone (3), 2,4'-dihydroxy-4,6-dimethoxydihydrochalcone (4), 4'-hydroxy-2,4,6-trimethoxydihydrochalcone (5), 4,6,4'-trihydroxy-2-methoxydihydrochalcone (6), 4,3',5'-trihydroxystilbene (7), 4,3'-dihydroxy-5'-methoxystilbene (8) and 4-hydroxy-3',5'-dimethoxystilbene (9) were isolated. These compounds were evaluated for their inhibitory activity against the enzymes cyclooxygenase-1 and cyclooxygenase-2. Potent but non-selective activity was found for the stilbenoids 7-9 (IC(50) 1.29 - 4.92 microM) whereas weak or no activity was observed for the flavonoids 1-6.
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