3-Hydroxybakuchiol

3-Hydroxybakuchiol
Product Name 3-Hydroxybakuchiol
CAS No.: 178765-54-3
Catalog No.: CFN92703
Molecular Formula: C18H24O2
Molecular Weight: 272.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Oil
Targets: Caspase | ATP
Source: The herbs of Psoralea corylifolia Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $368/10mg
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation.3-Hydroxybakuchiol has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Toxicol In Vitro.2019, 59:161-178
  • Appl Biol Chem2019, 62:46
  • Sci Rep.2018, 8(1)
  • Am J Chin Med.2015, 30:1-22
  • Molecules.2019, 24(20):3755
  • Int J Biol Macromol.2019, 126:653-661
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Academic J of Second Military Medical University2019, 40(1)
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Nutrients.2019, 11(6):E1380
  • 12-Hydroxyisobakuchiol

    Catalog No: CFN92702
    CAS No: 178765-55-4
    Price: Inquiry(manager@chemfaces.com)
    Delta3,2-Hydroxylbakuchiol

    Catalog No: CFN92803
    CAS No: 178765-49-6
    Price: Inquiry(manager@chemfaces.com)
    Bakuchiol

    Catalog No: CFN99047
    CAS No: 10309-37-2
    Price: $40/20mg
    3-Hydroxybakuchiol

    Catalog No: CFN92703
    CAS No: 178765-54-3
    Price: $368/10mg
    Psoracorylifol A

    Catalog No: CFN92704
    CAS No: 879290-97-8
    Price: Inquiry(manager@chemfaces.com)
    Psoracorylifol C

    Catalog No: CFN92804
    CAS No: 879290-99-0
    Price: Inquiry(manager@chemfaces.com)
    Toxicol Appl Pharmacol. 2013 Oct 15;272(2):356-64.
    Tumor cell death induced by the inhibition of mitochondrial electron transport: the effect of 3-hydroxybakuchiol.[Pubmed: 23777606]
    Changes in mitochondrial ATP synthesis can affect the function of tumor cells due to the dependence of the first step of glycolysis on mitochondrial ATP. The oxidative phosphorylation (OXPHOS) system is responsible for the synthesis of approximately 90% of the ATP in normal cells and up to 50% in most glycolytic cancers; therefore, inhibition of the electron transport chain (ETC) emerges as an attractive therapeutic target.
    METHODS AND RESULTS:
    We studied the effect of a lipophilic isoprenylated catechol, 3-Hydroxybakuchiol (3-OHbk), a putative ETC inhibitor isolated from Psoralea glandulosa. 3-OHbk exerted cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induced a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial permeability transport pore (MPTP) and nuclear DNA fragmentation. Additionally, 3-OHbk inhibited oxygen consumption, an effect that was completely reversed by succinate (an electron donor for Complex II) and duroquinol (electron donor for Complex III), suggesting that 3-OHbk disrupted the electron flow at the level of Complex I. The inhibition of OXPHOS did not increase the level of reactive oxygen species (ROS) but caused a large decrease in the intracellular ATP level. ETC inhibitors have been shown to induce cell death through necrosis and apoptosis by increasing ROS generation. Nevertheless, we demonstrated that 3-OHbk inhibited the ETC and induced apoptosis through an interaction with Complex I. By delivering electrons directly to Complex III with duroquinol, cell death was almost completely abrogated.
    CONCLUSIONS:
    These results suggest that 3-OHbk has antitumor activity resulting from interactions with the ETC, a system that is already deficient in cancer cells.
    Glycitein

    Catalog No: CFN99106
    CAS No: 40957-83-3
    Price: $128/20mg
    Sophoraflavanone G

    Catalog No: CFN92005
    CAS No: 97938-30-2
    Price: $138/20mg
    Ganoderic acid H

    Catalog No: CFN92056
    CAS No: 98665-19-1
    Price: $399/5mg
    Syringaresinol

    Catalog No: CFN92060
    CAS No: 487-35-4
    Price: $268/5mg
    Chebulagic acid

    Catalog No: CFN92295
    CAS No: 23094-71-5
    Price: Inquiry(manager@chemfaces.com)
    Piplartine

    Catalog No: CFN96137
    CAS No: 20069-09-4
    Price: $100/20mg
    Ganoderic acid G

    Catalog No: CFN90801
    CAS No: 98665-22-6
    Price: $400/10mg
    Isoformononetin

    Catalog No: CFN95024
    CAS No: 486-63-5
    Price: $288/5mg
    Cistantubuloside C1

    Catalog No: CFN95121
    CAS No: 620632-36-2
    Price: $298/10mg
    New compound 2

    Catalog No: CFN95181
    CAS No: N/A
    Price: $318/5mg