3,4,5-Trimethoxycinnamyl alcohol
3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
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Naunyn Schmiedebergs Arch Pharmacol.2024, 03148-x.
J Cell Mol Med.2022, 26(23):5807-5819.
J Appl Toxicol.2020, 40(7):965-978.
Food Science and Human Wellness2022, 11(4):965-974
BMC Complement Altern Med.2018, 18(1):221
Horticulturae2021, 7(1),5.
Toxicol In Vitro.2023, 93:105667.
Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
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Fitoterapia. 2003 Apr;74(3):308-11.
Antimicrobial and cytotoxic constituents of Loranthus globosus.[Pubmed:
12727502]
METHODS AND RESULTS:
(+)-Catechin, 3,4-dimethoxycinnamyl alcohol and 3,4,5-Trimethoxycinnamyl alcohol were isolated from the barks of Loranthus globosus. All compounds showed significant antimicrobial and cytotoxic activities.
Pak J Biol Sci. 2007 Jun 15;10(12):2073-7.
Toxicological studies of two compounds isolated from Loranthus globosus Roxb.[Pubmed:
19093449]
METHODS AND RESULTS:
The sub-acute toxicities of two compounds 3,4-dimethoxycinnamyl alcohol (1) and 3,4,5-Trimethoxycinnamyl alcohol (2) isolated from the plant Loranthus globosus Roxb were studied on long Evan's rats. The studies included the gross general observation such as changes in body weight, haematological profiles [total count of Red Blood Cells (RBC) and White Blood Cells (WBC), differential count of WBC, platelet count and Haemoglobin (Hb)%], biochemical parameters of blood [Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (SALP), urea and creatinine) and histopathology of the liver, kidney, heart and lung of both control and experimental groups of rats. The changes in haematological and biochemical parameters were statistically not significant after the administration of compounds 1 and 2 in a dose of 300 microg/rat/day for consecutive 14 days. No abnormality was found in the histopathology of the liver, kidney, heart and lung in the experimental groups of rats following same dose when compared with control group.
CONCLUSIONS:
This preliminary study suggests that the isolated compounds may be used safely for clinical trial.
