(2R,3S)-Dihydrodehydroconiferyl alcohol
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Molecules.2019, 24(1):E159
J Liq Chromatogr R T2025, 2505536.
Pharmacol Res.2020, 161:105205.
Toxicol Res.2019, 35(4):371-387
Anal Bioanal Chem.2016, 408(1):177-90.
Korea Food Research Institute2024, 4798082
Prev Nutr Food Sci.2025, 30(1):92-100.
J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
Sci Rep.2017, 7(1):3249
Applied Biological Chem. 2020, 26(63).
Related and Featured Products
Arch Pharm Res. 2005 Dec;28(12):1337-40.
Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells.[Pubmed:
16392665]
METHODS AND RESULTS:
A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol ((2R,3S)-Dihydrodehydroconiferyl alcohol,DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 microM caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 microM, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C (PKC) inhibitor.
CONCLUSIONS:
These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
3,3',4',5,6,7,8-heptamethoxyflavone
Catalog No: CFN95021
CAS No: 1178-24-1
Price: $268/10mg
20-O-Glucoginsenoside Rf
Catalog No: CFN95036
CAS No: 68406-27-9
Price: $318/5mg
Parvisoflavanone
Catalog No: CFN95077
CAS No: 49776-79-6
Price: $413/5mg
Isocarlinoside
Catalog No: CFN95092
CAS No: 83151-90-0
Price: $318/5mg
Methyl caffeate acid
Catalog No: CFN95561
CAS No: 3843-74-1
Price: Inquiry(manager@chemfaces.com)
Arisanschinin E
Catalog No: CFN95221
CAS No: 1333378-33-8
Price: Inquiry(manager@chemfaces.com)
Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)
Catalog No: CFN95315
CAS No: 1218774-64-1
Price: $318/5mg
Methyl 2-hydroxy-3,4-dimethoxybenzoate
Catalog No: CFN95383
CAS No: 6395-23-9
Price: $268/5mg
3',8-Dihydroxyvestitol
Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
(Z)-3,11-dimethy-7-methylene-9,14-epoxy-1,6,10-dodecatrien-3-ol
Catalog No: CFN95402
CAS No: 1392202-57-1
Price: $318/10mg
