25R-Inokosterone

25R-Inokosterone
Product Name 25R-Inokosterone
CAS No.: 19682-38-3
Catalog No.: CFN93572
Molecular Formula: C27H44O7
Molecular Weight: 480.6 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Targets: TNF-α | IFN-γ
Source: The roots of Achyranthes bidentata Blume.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2021, 26(9):2765.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Molecules.2023, 28(7):3039.
  • Pharmacol Res.2022, 182:106346.
  • Sci Rep.2023, 13(1):14594.
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Food Chem.2021, 337:128023.
  • Molecules.2019, 24(9):E1719
  • Nutrients.2018, 10(12):E1998
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    Journal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.
    Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity[Reference: WebLink]
    The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling.
    METHODS AND RESULTS:
    Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-inokosterone (2), and 25R-Inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80–95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
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    As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.
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    CONCLUSIONS:
    The results indicate that the established HPLC/UV method is suitable for quantitation and pattern recognition analyses for quality evaluation of Achyranthis Radix.
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