1alpha-Hydroxytorilin
1alpha-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Biomed Pharmacother.2024, 173:116319.
Applied Biological Chemistry2022, 65(12)
Phytomedicine.2019, 57:95-104
National University of Pharmacy2022, 1:73-76
Biochem Biophys Res Commun.2020, 530(1):4-9.
Environ Toxicol.2024, 39(3):1556-1566.
J Agric Food Chem.2024, acs.jafc.4c01387.
Pharmacol Rep.2018, 70(6):1195-1201
Applied Biological Chemistry 2022, 65,5(2022).
J Cosmet Dermatol.2022, 21(1):396-402.
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Arch Pharm Res. 2006 Feb;29(2):131-4.
Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines.[Pubmed:
16526276]
METHODS AND RESULTS:
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-Hydroxytorilin, 3) by spectroscopic analysis.
CONCLUSIONS:
Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
