19-Oxocinobufotalin
19-Oxocinobufotalin 3-adipoylarginine ester shows significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Molecules.2018, 23(10):E2638
Phytother Res.2020, 34(4):788-795.
J Sep Sci.2021, 44(22):4064-4081.
Front Pharmacol.2022, 13:972825.
University of East Anglia2023, 93969.
Korean J of Crop Science2019, 452-458
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J Asian Nat Prod Res. 2011 Feb;13(2):111-6.
Cytotoxic constituents from the skin of the toad Bufo bufo gargarizans.[Pubmed:
21279874 ]
METHODS AND RESULTS:
To study the chemical composition of the skin of Bufo bufo gargarizans, various chromatographic methods were used in the isolation procedures and the structures of isolated compounds were determined based on NMR and MS analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-N-methylurea (1) and 19-Oxocinobufotalin 3-adipoylarginine ester (2), together with 11 known compounds.
CONCLUSIONS:
Isolated bufadienolides showed significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
Helvetica Chimica Acta, 1969, 52(4):1097–1101.
über neue Bufadienolide aus Ch'an Su. über Krötengifte, 34. Mitteilung.[Reference:
WebLink]
Two new bufadienolides, isolated from Ch'an Su, are proved to be 19-Oxocinobufagin (III) and 19-Oxocinobufotalin (V), respectively.
