16beta,17-Dihydroxy-ent-kaurane-19-oic acid
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosity depression.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 1996 Jun;59(6):635-7.
Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa.[Pubmed:
8786370 ]
METHODS AND RESULTS:
Phytochemical analysis of the fruits of Annona squamosa yielded 12 known kaurane derivatives (1-11, 13) and two new kaurane diterpenoids, which have been named annosquamosin A (16 beta-hydroxy-17-acetoxy-ent-kauran-19-al) (12) and annosquamosin B (19-nor-ent-kaurane-4 alpha,16 beta,-17-triol) (14). The structures of the new compounds were established by spectral analyses and chemical evidence.
CONCLUSIONS:
Among these 14 compounds, 16 beta, 17-dihydroxy-ent-kauran-19-oic acid (16beta,17-Dihydroxy-ent-kaurane-19-oic acid, 2) showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL (therapeutic index > 5).
Yao Xue Xue Bao. 2007 Feb;42(2):166-70.
Diterpenes from Helianthus annuus and their cytotoxicity in vitro.[Pubmed:
17518044]
METHODS AND RESULTS:
To search for bioactive compounds from the flower disc of Helianthus annuus L., chromatography was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities, some compounds showed moderate cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines. Eleven compounds were obtained from the flower disc of H. annuus, and identified as ent-kaurane-2alpha, 16alpha-diol (1) and entkaurane-15alpha,16alpha-epoxy-17-al-19-oic acid (2), and nine known diterpenes, ent-kaurane-16P-ol (3), phyllocladan-16beta-ol (4) , ent-atisan-16a-ol (5) , grandifloric acid (6) , angeloylgrandifloric acid (7), ent-kaurane-16-en-19-oic acid (8), ent-kaurane-17-hydroxy-15-en-19-oic acid (9), ent-kaurane-16beta, 17-dihydroxy-19-oic acid (16beta,17-Dihydroxy-ent-kaurane-19-oic acid,10), and ciliaric acid (11).
CONCLUSIONS:
Compounds 1 and 2 are new compounds, some compounds showed cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines.
Baiqiuen Yike Daxue Xuebao,Jan 2001, 27(5):472-474.
Effects of ent-16#beta#, 17-dihydroxy-kauran-19-oic acid on decompression and blood viscosity[Reference:
WebLink]
METHODS AND RESULTS:
ABP, LVSP, ±dp/dt_(max), HR, DBP and blood viscosity of rabbits were depressed after duodenum administration compared with before drug. ent-16#beta#, 17-dihydroxy-kauran-19-oic acid(16beta,17-Dihydroxy-ent-kaurane-19-oic acid)possesses the activities of decompression and blood viscosity depression.
