1-Methyl-2-nonylquinolin-4(1H)-one
1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
PLoS One.2017, 12(3):e0173585
Int J Mol Sci.2022, 23(21):13406.
Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
Univerzita Karlova2022, 228192.
Cell Physiol Biochem.2017, 43(4):1425-1435
Pharmaceuticals (Basel).2024, 17(10):1368.
Molecules.2018, 23(12):E3103
J Biomol Struct Dyn.2023, 1-21.
The Journal of Agromedicine and Medical Sciences2018, 4(1)
BMC Complement Altern Med.2018, 18(1):221
Related and Featured Products
Planta Med. 2004 Oct;70(10):904-8.
Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa.[Pubmed:
15490316]
METHODS AND RESULTS:
The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes.
Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone(1-Methyl-2-nonylquinolin-4(1H)-one), 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively.
CONCLUSIONS:
Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.
Polygalasaponin XLIX
Catalog No: CFN95117
CAS No: 1033593-12-2
Price: $318/10mg
3,7,25-Trihydroxycucurbita-5,23-dien-19-al
Catalog No: CFN95150
CAS No: 85372-65-2
Price: $318/5mg
(1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate
Catalog No: CFN95161
CAS No: 201012-14-8
Price: $318/10mg
Isonardosinone
Catalog No: CFN95180
CAS No: 27062-01-7
Price: $318/10mg
Phloretin 3',5'-Di-C-glucoside
Catalog No: CFN95306
CAS No: 357401-40-2
Price: $318/10mg
Parishin G
Catalog No: CFN95324
CAS No: 952283-93-1
Price: $318/10mg
12beta-Acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20-diene-26-oic acid
Catalog No: CFN95468
CAS No: 1085338-75-5
Price: $318/5mg
8-Epiloganin
Catalog No: CFN95478
CAS No: 79172-04-6
Price: $318/20mg
Methyl lucidenate C
Catalog No: CFN95541
CAS No: N/A
Price: $413/5mg
Calleryanin
Catalog No: CFN95556
CAS No: 20300-53-2
Price: $318/5mg