Aucklandia lappa

Aucklandia lappa is a plant whose rhizome is commonly used in Traditional Chinese medicine. Compounds in the rhizome are thought to have anti-fungal, anti-oxidant and anti-cancer properties. Dehydrocostuslactone and costunolide have been isolated from the rhizome.
Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costunolide, dehydrocostus lactone, and alantolactone, isolated from a 70% methanolic extract of Aucklandia lappa, on the expression of chemokine mRNA in HaCaT human keratinocyte cells. The cytotoxicities of the compounds on HaCaT cells were evaluated using a Cell Counting Kit8 assay. Furthermore, the inhibitory effects of the three compounds on chemokine expression in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated HaCaT cells were analyzed by reverse transcription-polymerase chain reaction analysis.

Research products of this plants
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg
Isoalantolactone

Catalog No: CFN98107
CAS No: 470-17-7
Price: $40/20mg
Alantolactone

Catalog No: CFN99934
CAS No: 546-43-0
Price: $30/20mg
Beta-Sitosterol

Catalog No: CFN99916
CAS No: 83-46-5
Price: $40/20mg
Stigmasterol

Catalog No: CFN97326
CAS No: 83-48-7
Price: $30/20mg
Palmitic acid

Catalog No: CFN99716
CAS No: 57-10-3
Price: $30/20mg
Linoleic acid

Catalog No: CFN93168
CAS No: 60-33-3
Price: $30/20mg
beta-Costic acid

Catalog No: CFN98498
CAS No: 3650-43-9
Price: $318/10mg
Betulin

Catalog No: CFN98710
CAS No: 473-98-3
Price: $30/20mg
5beta-Hydroxycostic acid

Catalog No: CFN99405
CAS No: 132185-84-3
Price: Inquiry(manager@chemfaces.com)
5alpha-Hydroxycostic acid

Catalog No: CFN99404
CAS No: 132185-83-2
Price: $318/5mg
Syringin

Catalog No: CFN99282
CAS No: 118-34-3
Price: $80/20mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Sulfocostunolide B

Catalog No: CFN99075
CAS No: 1059671-65-6
Price: Inquiry(manager@chemfaces.com)
Sulfocostunolide A

Catalog No: CFN99030
CAS No: 1016983-51-9
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1beta-Hydroxyalantolactone

Catalog No: CFN92600
CAS No: 68776-47-6
Price: $318/10mg
7,4-Di-O-methylapigenin 5-O-glucoside

Catalog No: CFN99900
CAS No: 197018-71-6
Price: Inquiry(manager@chemfaces.com)
Isocostic acid

Catalog No: CFN97186
CAS No: 69978-82-1
Price: Inquiry(manager@chemfaces.com)
Methyl isocostate

Catalog No: CFN99408
CAS No: 132342-55-3
Price: Inquiry(manager@chemfaces.com)
Ascleposide E

Catalog No: CFN98414
CAS No: 325686-49-5
Price: Inquiry(manager@chemfaces.com)