Cytotoxic

Effusanin A
Catalog No: CFN98377

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 microM, and LoVo cells with IC50 value of 3.02 microM.

3,4,5-Trimethoxycinnamyl alcohol
Catalog No: CFN98379

3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.

Centrolobol
Catalog No: CFN98383

(-)-Centrolobol has antifibrotic activity, it can significantly inhibit the proliferation of HSC-T6 cells in a dose-dependent manner. Centrolobol exhibits strong cytotoxic activity against KB cell line.

Isobavachin
Catalog No: CFN98400

Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells.

8-Deoxygartanin
Catalog No: CFN98427

8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced β-amyloid (Aβ) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD. 8-Deoxygartanin has antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. 8-Deoxygartanin has cytotoxic effect on human melanoma cells, it inhibits p65 activation with IC50 values of 11.3 microM, it is a potential candidate as anti-melanoma agents.