Cytotoxic

Eichlerialactone
Catalog No: CFN98092

Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25–50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gram-positive pathogens. Eichlerialactone is weakly cytotoxic to a breast cancer (BC) cell line.

Evodiamine
Catalog No: CFN99993

Evodiamine, a novel non-pungent vanilloid receptor agonist, which has the effects of anti-obese, analgesic, vasodilator, anti-oxidation, anti-inflammatory and anti-cancer. It prevents the accumulation of perivisceral fat and the body weight increase, blocks of the Ca2+ influx through receptor-mediated Ca2+ channels, inhibits NF-kB activation through suppression of IkB kinase activity.

Erysubin A
Catalog No: CFN98097

Erysubin A , wighteone, and lupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM).

alpha-Amyrin palmitate
Catalog No: CFN98210

alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki=6 microM), it also shows weak cytotoxicity against the A2780 human ovarian cancer cell line.

6-Acetonyldihydrochelerythrine
Catalog No: CFN98233

6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 cell lines, it displays potent cytotoxic activity in human HCT116 and SW620 colon carcinoma cells, to a higher extent than 5-fluorouracil (5-FU), the cornerstone chemotherapeutic agent in colon cancer.