Cytotoxic

Beta-mangostin
Catalog No: CFN99723

Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity against B. cereus, and Mycobacterium tuberculosis with the MIC value of 0.25, and 6.25 microg/ml, respectively. It also shows antimalarial activity against Plasmodium falciparum with IC(50) values of 7.2 microg/ml.
Catalpalactone
Catalog No: CFN99670

Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities and enhance L-DOPA- induced cytotoxiciy in PC12 cells. Catalpalactone also exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells.
Sambutoxin
Catalog No: CFN99672

Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin. Sambutoxin has in vitro cytotoxicity against various human and murine tumor cells and values of sambutoxin ranged from 46.2 to 1,425.6 ng/ml. It inhibits rabbit platelet aggregation, which may be party due to the decrease of ATP release.
Alisol B 23-acetate
Catalog No: CFN99753

Alisol B 23-acetate, a partial non-competitive inhibitor of P-gp, it may be a potential MDR reversal agent. Alisol B 23-acetate produces protective effects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated gene regulation; it obviously inhibits proliferation of the three ovarian cancer cell lines, possesses anti-proliferation, anti-migration and anti-invasion activities as a single agent on ovarian cancer cells.
Villosin C
Catalog No: CFN99676

Villosin C and villosin B have remarkable cytotoxic effects against four cancer cell lines (A549, HepG-2, MCF-7 and 4T1), with IC50 values ranging from 8.79 to 35.46 microM.