Antimalaric

Lapachol
Catalog No: CFN97403

Lapachol shows both antimicrobial, trypanocidal and antiviral activities, it also shows antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Probiotics are capable of converting Lapachol into the most effective cytotoxic compound against a breast cancer cell line.

11(13)-Dehydroivaxillin
Catalog No: CFN97438

11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

Walsuronoid B
Catalog No: CFN97517

Walsuronoid B shows weak antimalarial activity.

Quinine
Catalog No: CFN90195

Quinine is an anti-malaria agent and also a potassium channel inhibitor with an IC50 of 169 μM.Quinine is used for the treatment of acute malaria in pregnant women.

Akuammigine
Catalog No: CFN97710

Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. Akuammidine also shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively.