Antimalaric

Artesunate
Catalog No: CFN90313

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.Artesunate has anti-inflammatory activity, can prevent neuroinflammation in BV2 microglia by interfering with NF-κB and p38 MAPK signalling.

1,2-Dihydrotanshinquinone
Catalog No: CFN90333

1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Lycorenine
Catalog No: CFN90363

Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyphylaxis to the vasodepressor action of lycorenine is ascribed to maintenance of its alpha-adrenergic blocking action.

Eurycomanone
Catalog No: CFN92008

Eurycomanone has anti-cancer activity, it is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.

7-Methoxy-beta-carboline-1-propionic acid
Catalog No: CFN92013

7-Methoxy-beta-carboline-1-propionic acid demonstrates significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains.