Anticancer

Cannabigerol
Catalog No: CFN98287

Cannabigerol is a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma. Cannabigerol has antimicrobial and antifungal activity, It exhibits the highest growth-inhibitory activity against the cancer cell lines. Cannabigerol is also a novel, well-tolerated appetite stimulant in pre-satiated rats.

Germacrone
Catalog No: CFN98133

Germacrone has anti-tumor activity, it can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung. Germacrone also moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates.

Platycodin D
Catalog No: CFN98134

Platycodon D shows antinociceptive, and anti-inflammatory activities, it can induce autophagy in NCI-H460 and A549 cells through inhibiting PI3K/Akt/mTOR signaling pathway and activating JNK and p38 MAPK signaling pathways. Platycodon D can inhibit migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Platycodin D is also a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen.

2,3-Dihydroxy-12-oleanen-28-oic acid
Catalog No: CFN98310

2,3-Dihydroxy-olean-12-en-28-oic acids show a low cytotoxicity towards several human tumor cell lines.

Praeruptorin D
Catalog No: CFN98142

Praeruptorin D exhibits antitumor and anti-inflammatory activities, it protects mice from hydrochloric acid (HCl)-induced lung injury by inhibiting PMNs influx, IL-6 release and protein exudation. Praeruptorin D can significantly up-regulate CYP3A4 expression and activity via the Pregnane X receptor (PXR)-mediated pathway.