Anticancer

gamma-Mangostin
Catalog No: CFN98396

gamma-Mangostin is a dual agonist that activates both PPARδ and PPARα, is also a novel competitive antagonist for the 5-HT2A receptors in vascular smooth muscles and platelets.gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells, and exhibits antihypertensive, anti-inflammatory, analgesic effects. gamma-Mangostin could as a preventive agent of the metabolic syndrome, and could serve as a micronutrient for colon cancer prevention.

Myricanone
Catalog No: CFN98413

Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-κB and STAT3 signalling cascades. Myricanone shows in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice.

4-Methoxycinnamic acid
Catalog No: CFN98191

4-Methoxycinnamic acid is a photosensitive compound, it shows various pharmacologic actions such as anti-cancer, hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels. 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible.

2-Hydroxycinnamic acid
Catalog No: CFN98193

2-Hydroxycinnamic acid has photooxidant activity; 2-hydroxycinnamic acid germanium has strong inhibitory effect on the tumor U14; trans-2-hydroxycinnamic acid has efficacy against trichlorfon-induced oxidative stress in wistar rats.

Kaempferol 3-neohesperidoside
Catalog No: CFN98415

Kaempferol 3-neohesperidoside has insulin-like properties in terms of glucose lowering, it stimulates glucose uptake in the rat soleus muscle via the PI3K and PKC pathways and, at least in part, independently of MEK pathways and the synthesis of new glucose transporters. Kaempferol 3-neohesperidoside possesses not only a significant anticancer effect against HepG2 cells, but also an effective and a dose dependent hepatoprotective and antioxidant activities due to the presence of flavonoids content.