Hot Products

Praeruptorin B
Catalog No: CFN98140

Praeruptorin B has significant important phase II drug-metabolizing enzymes uridine 5'-diphospho-glucuronosyltransferase (UGTs) isoforms inhibition activity. Praeruptorin B and praeruptorin A have LC 50 values of 34.5 and121.2 ug/ml, respectively, in Artemia salina test .

Praeruptorin C
Catalog No: CFN98143

Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases, it partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family. It has cardioprotective effect , it can reduce vascular hypertrophy in isolated rat hypertrophied smooth muscle cells, is important in prevention and treatment of vascular hyperplastic disease.

Praeruptorin D
Catalog No: CFN98142

Praeruptorin D exhibits antitumor and anti-inflammatory activities, it protects mice from hydrochloric acid (HCl)-induced lung injury by inhibiting PMNs influx, IL-6 release and protein exudation. Praeruptorin D can significantly up-regulate CYP3A4 expression and activity via the Pregnane X receptor (PXR)-mediated pathway.

Praeruptorin E
Catalog No: CFN90449

Praeruptorin E is a cardiotonic agent with selective cardiac calcium channel agonistic effect, it can relax swine coronary artery and decrease contractility in guinea-pig left atria. Praeruptorin E may be useful in the therapy of lung injury, it can protect mice from hydrochloric acid (HCl)-induced lung injury by inhibiting polymorphonuclear leukocytes (PMNs) influx, IL-6 release and protein exudation.

Pratensein
Catalog No: CFN90805

Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. Pratensein has anti-inflammatory activity, it has robust activation of acetylcholinesterase expression, the induction of acetylcholinesterase included the levels of mRNA, protein and enzymatic activity; it can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment through reducing neuroinflammation via inhibition of glial activation and NF-κB activation, and restoring synapse and BDNF levels.

Precocene II
Catalog No: CFN97708

Precocene II , an insect growth regulator, it inhibits the production of juvenile hormone (JH) in insects, it is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis. Precocene II is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats.

Precyasterone
Catalog No: CFN90613

Reference standards.

Pregabalin
Catalog No: CFN90013

Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients.Pregabalin (30 and 100mg/kg) presents central spinal but not central supraspinal antinociceptive effect and Pregabalin 100mg/kg shows peripheral antinociceptive effect. Pregabalin may be effective for the reduction of neuropathic pain, it improves postoperative analgesia compared with placebo at the expense of increased sedation and visual disturbances.

Pregnenolone
Catalog No: CFN99497

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively. Pregnenolone has memory-enhancing effects, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.

Pregomisin
Catalog No: CFN96694

Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.