Hot Products

Officinaruminane B
Catalog No: CFN92687

Standard reference

Ohchinin
Catalog No: CFN97704

Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm).

Okanin
Catalog No: CFN90849

1. Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
2. Okanin shows significant protective effects against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC50 value of 29.8±1.1 uM.
3. Okanin can inhibit nitric oxide production and inducible nitric oxide synthase expression via nuclear factor-erythroid 2-related factor 2-dependent heme oxygenase-1 expression in lipopolysaccharide-activated macrophages.
4. Okanin attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways, suggests that okanin may have potential as a nutritional preventive strategy for neurodegenerative disorders.

Olaparib (AZD2281)
Catalog No: CFN60045

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.

Olaquindox
Catalog No: CFN90395

Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induces apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway, might be suppressed through p38 MAPK and ROS-JNK pathways; it induces autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK.Olaquindox has genotoxic activity.

Oleacein
Catalog No: CFN70276

Oleacein has antioxidant, anti-metastatic, anticancer, and anti-inflammatory activities, it inhibits STAT3, activates the apoptotic machinery. Oleacein can be used as an adjuvant to improve insulin sensitivity in humans, and it could play a potential role in the prevention of inflammatory disease related to atherosclerosis.

Olean-12-ene-3,11-diol
Catalog No: CFN98871

Reference standards.

Oleandrin
Catalog No: CFN98693

Oleandrin has anticarcinogenic, anti-inflammatory, and growth-modulatory effects , which may thus be partially ascribed to the inhibition of activation of NF-κB and AP-1 and potentiation of apoptosis; it has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.Oleandrin inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.

Oleanolic acid
Catalog No: CFN98800

Oleanolic acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor, anti-inflammatory, antioxidant, and antiviral properties. Oleanolic acid exhibits anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as a noncompetitive inhibitor; it induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways; can be employed as a lead in the development of potent NO inhibitors. Oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway.

Oleaside A
Catalog No: CFN90884

Oleaside A is a natural product from Nerium oleander.