Hot Products

Irigenin
Catalog No: CFN93276

Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Irigenin displays moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells.

Irilone
Catalog No: CFN93694

Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines, it protected dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation.

Irinotecan hydrochloride
Catalog No: CFN90886

Irinotecan hydrochloride is a water soluble topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.

Irisflorentin
Catalog No: CFN99788

Irisflorentin has anti-inflammatory activity, it can markedly reduce the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO, it also can significantly inhibit TNF-α, IL-1βand IL-6 at both the transcriptional and translational levels; Irisflorentin has potential to ameliorate Parkinson’s disease in Caenorhabditis elegans models by promoting rpn-3 expression and down-regulating egl-1 expression; Irisflorentin may as an immunotherapeutic adjuvant.

Irisolidone
Catalog No: CFN93085

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 uM. Irisolidone shows anti-inflammatory, anti-platelet aggregation, hepatoprotective, and α-amylase inhibitory activities, it may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion. Irisolidone shows potent inhibitory activity against Helicobacter pylori. Irisolidone also shows antiproliferative activity against amelanotic melanoma cells.

Iristectorigenin A
Catalog No: CFN91672

Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant hepatoprotective activity.

Iristectorin A
Catalog No: CFN95037

Iristectorin A is a natural product from Iris tectorum.

Isatidine
Catalog No: CFN00408

Isatidine and sceleratine slightly raise blood pressure in cats following intravenous injection, and stimulate isolated guinea pigs' uteri. Isatidine shows in vitro genotoxicity in Hep G2/SCGE assays.

Isoacteoside
Catalog No: CFN97049

Isoacteoside exhibits significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM; it has neuroprotective, antioxidant, and anti-inflammatory effects. Isoacteoside can stimulate the increase of α7 and α3 proteins in the cultured cells, attenuate the decreased expression of α3 and α7 nAChR subunit proteins and cell viability on SH-SY5Y cells induced by Aβ; it can regulate caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.

Isoagarotetrol
Catalog No: CFN91076

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