Hot Products

Isochamaejasmine
Catalog No: CFN92150

Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L. Isochamaejasmine shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited.

Isochlorogenic acid A
Catalog No: CFN99118

Isochlorogenic acid A has antiviral, antioxidant, hepatoprotective and potent anti-hepatitis B activities.

Isochlorogenic acid B
Catalog No: CFN99119

Isochlorogenic acid B has antioxidant activity, it is a potential PDE-5 inhibitor.

Isochlorogenic acid C
Catalog No: CFN99120

Isochlorogenic acid C possesses potent hepatoprotective and anti-HBV effects, its anti-apoptotic and anti-injury effects could be achieved by its anti-oxidative properties and interfering the caspase-3 and TGF-β1 expressions.

Isochlorogenic acid C(4,5)
Catalog No: CFN90354

Isochlorogenic acid C(4,5) has antiviral activity, including anti-HIV-1 integrase activity. It shows anti-hepatotoxic activity.

Isocorynoxeine
Catalog No: CFN98155

Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage, it exhibits a significant neuroprotective effect against glutamate-induced HT22 cell death at the maximum concentration.

Isocryptotanshinone
Catalog No: CFN90355

Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.

Isocucurbitacin B
Catalog No: CFN91003

Isocucurbitacin B has significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.

Isocucurbitacin D
Catalog No: CFN95326

Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.Isocucurbitacin D dose-dependently increased LDLR protein levels and decreased PCSK9 protein levels.

Isocupressic acid
Catalog No: CFN99882

Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial cells of the uterine tissue results in abortion. Isocupressic acid shows strong inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction (100 % inhibition at 1000 mol ratio/12-O-tetradecanoylphorbol 13-acetate (TPA).