Hot Products

Herbacetin
Catalog No: CFN99778

Herbacetin, a novel Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators. Herbacetin also has a strong ability to scavenge free radical and inhibit oxidative protein damage.

Hernandezine
Catalog No: CFN89519

Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). Hernandezine is a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells, it induces autophagic cell death in drug-resistant cancers. Hernandezine inhibits calcium-depletion stimulated calcium entry in human and bovine endothelial cells.

Hesperetin
Catalog No: CFN98842

Hesperetin has antioxidative and anti-inflammatory effects, it inhibits vascular formation by endothelial cells via the inhibition of the PI3K/AKT, ERK and p38 MAPK signaling. Hesperetin-mediated apoptosis of MCF-7 cells involves accumulation of ROS and activation of ASK1/JNK pathway, it induces apoptosis in triple negative breast cancer MDA-MB-231 cells via intrinsic pathway via activation of caspase -9 and -3 and increase in Bax:Bcl-2 ratio.

Hesperetin 5-O-glucoside
Catalog No: CFN96023

Hesperetin 5-O-glucoside has hypocholesterolemic effect.

Hesperetin 7-O-glucoside
Catalog No: CFN98405

Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.

Hesperidin
Catalog No: CFN98839

Hesperidin has antioxidative, anti-inflammatory, vasoprotective,and anticarcinogenic effects, it induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Hesperidin also exerts its protective effect against CYP-induced hepatotoxicity through upregulation of hepatic PPARγ expression and abrogation of inflammation and oxidative stress.

Hesperidin methylchalcone
Catalog No: CFN80405

Hesperidin methylchalcone has anti-inflammatory effects, it can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation. Hesperidin methylchalcone can regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Hesperidin methylchalcone has a protective effect against leakage of FITC-dextran in the cheek pouch after administration of various permeability-increasing substances. It is a promising new therapeutic approach to protecting the skin from the deleterious effects of UVB irradiation.

Heterophyllin B
Catalog No: CFN90627

Heterophyllin B is used as the quality control index for evaluating P. heterophylla in the Chinese Pharmacopoeia.Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes.

Hexahydrocurcumin
Catalog No: CFN97749

Hexahydrocurcumin has in vitro antioxidant and anti-inflammatory activities, it has potential beneficial effects as a food and/or dietary supplement. Hexahydrocurcumin has cytotoxic effect, may prove useful in cancer prevention, it together with 5-fluorouracil exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer. Hexahydrocurcumin is also an anti-atherosclerogenic agent in humans, can inhibit platelet aggregation in the treatment of human platelet-rich plasma.

Hexamethylquercetagetin
Catalog No: CFN93128

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