Hot Products

Flavoglaucin
Catalog No: CFN96893

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammatory effects, it shows inhibitory effects on inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Flavoglaucin exhibits a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with theIC(50) value of 11.3 microM.

Flavokawain A
Catalog No: CFN98446

Flavokawain A is an apoptotic inducer and immune- modulator ,it also shows anti-inflammatory, and anti-tumor activities.Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.Flavokawain A may suppress LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

Flavokawain B
Catalog No: CFN92661

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. Flavokawain B has potent anti-inflammatory, and anti-cancer activities, it can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Flavokawain C
Catalog No: CFN90741

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

Flavone
Catalog No: CFN70130

Flavone induces effectively programmed cell death, differentiation, and growth inhibition in transformed colonocytes by acting at the mRNA levels of genes involved in these processes. Because these genes play a crucial role in colon carcinogenesis, flavone may prove to be a potent new cytostatic compound with improved selectivity toward transformed cells.

Flavonol
Catalog No: CFN70151

Flavonol has antioxidant activity.

Fluorouracil
Catalog No: CFN60175

Folic acid
Catalog No: CFN98552

Folic acid supplementation improves arterial endothelial function in adults with relative hyperhomocystinemia, with potentially beneficial effects on the atherosclerotic process. Both local perfusion of 5-MTHF and supplementation with folic acid increase vasodilatation in ageing individuals through NO-dependent mechanisms. The combined use of enalapril and Folic acid significantly reduced the risk of first stroke, folic acid deficiency and homocysteine impaired DNA repair in hippocampal neurons and sensitized them to amyloid toxicity.

Foretinib (GSK1363089)
Catalog No: CFN60215

Formononetin
Catalog No: CFN99962

Formononetin is a phytoestrogen, could be used in postmenopausal osteoporosis. It has antitumorigenic effects, suppressed the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis; it also exhibits antiviral activities against some members of Picornaviridae, could inhibit EV71-induced COX-2 expression and PGE2 production via MAPKs pathway including ERK, p38 and JNK.