Cyperenone
Catalog No: CFN91594
Cyperotundone is a sesquiterpene isolated from Nagarmotha (Cyperus rotundus). Cyperotundone is an active constituent in Chuanxiong Rhizoma and Cyperi Rhizoma (CRCR) for treating migraine. In vitro studies demonstrated that Alpinia officinarum-Cyperus rotundus (HP G-X) and the corresponding single herbs significantly reduced IL-6, TNF-α, and COX-2. In vivo investigations indicated that HP G-X can protect the gastric mucosa of mice from ethanol-induced damage by inhibiting the inflammatory reaction and providing analgesia. It can also inhibit the expression of NF-κBp65, COX-2, and TRPV1 protein, reduce the concentrations of IL-6 and TNF-α, and relieve heat-induced pain.
Cytochalasin D
Catalog No: CFN98204
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis; it stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis. Cytochalasin D is also an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus.
