alpha-Bisabolol
alpha-Bisabolol has antitumorous and antimicrobial activities. Halitosis-associated bacterium S. moorei is susceptible to the antimicrobial agents tea tree oil and alpha-bisabolol, they might be beneficial in oral healthcare products. (-)-alpha-Bisabolol has gastroprotective effect on ethanol and indomethacin-induced ulcer
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Archives of Oral Biology,2013,58(3):10-16.
The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis.[Reference:
WebLink]
To investigate the antimicrobial effect of alpha-Bisabolol and tea tree oil alone and in combination against the halitosis-associated Gram-positive bacillus Solobacterium moorei.
The inhibitory activity of alpha-Bisabolol and tea tree oil against the reference strain S. moorei CCUG39336 and four clinical S. moorei isolates was investigated by a direct exposure test. Additionally, the ability of alpha-Bisabolol to increase the sensitivity of S. moorei was tested by pretreating the bacteria with sublethal concentrations prior to the administration of tea tree oil.
A dose-dependent killing was observed for the antimicrobial agents in a direct exposure test with the reference strain S. moorei CCUG39336. Concentrations of ≥0.5% tea tree oil caused decreases in viability of >5 log colony forming units/ml even after short incubation periods, while bacterial viability was less affected by alpha-Bisabolol. The combination of 0.1% alpha-Bisabolol plus 0.05% tea tree oil showed a synergistic effect on S. moorei strain CCUG39336 and on two of the four clinical S. moorei isolates tested. However, incubation of S. moorei with a sublethal concentration of 0.1% alpha-Bisabolol for three days prior to the administration of 0.05% tea tree oil did not enhance the antibacterial effect of tea tree oil.
CONCLUSIONS:
Halitosis-associated bacterium S. moorei is susceptible to the antimicrobial agents tea tree oil and alpha-Bisabolol, suggesting that these compounds might be beneficial in oral healthcare products.
Journal of Applied Phycology, 2016, 28(3):1987-1996.
Alpha-bisabolol from brown macroalga Padina gymnospora mitigates biofilm formation and quorum sensing controlled virulence factor production in Serratia marcescens.[Reference:
WebLink]
Biofilm formation, quorum sensing (QS)-regulated virulence and emergence of antibiotic resistance in bacterial pathogens lead to major health problems. In this perspective, antibiofilm agents and QS inhibitors have gained much attention to treat infections caused by antibiotic-resistant pathogens. For the first time, this investigation reports the antibiofilm and QS inhibitory potential of the brown macroalga Padina gymnospora against the nosocomial pathogen Serratia marcescens.
METHODS AND RESULTS:
The methanolic extract of P. gymnospora inhibited biofilm formation and the production of prodigiosin and protease. Successive solvent extraction, bioassay-guided fractionation of chloroform extract and GC-MS analysis of active fractions showed the presence of alpha-Bisabolol with a relative abundance of 69 %. In vitro assays with alpha-Bisabolol evidenced the potent inhibition of biofilm and QS-controlled prodigiosin, protease and swarming in S. marcescens, without exerting deleterious effect on its growth and metabolic activity.
CONCLUSIONS:
The results of this study exemplify the use of P. gymnospora and alpha-Bisabolol as promising alternatives to antibiotics.
Fundamental and Clinical Pharmacology, 2009, 24(1):63-71.
Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms.[Reference:
WebLink]
(-)-alpha-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla.
(-)-alpha-Bisabolol has generated considerable economic interest, since it possesses a delicate floral odor and has been shown to have anti-septic and anti-inflammatory activity. The aim of this work was to evaluate the gastroprotective action of (-)-alpha-Bisabolol on ethanol and indomethacin-induced ulcer models in mice, and further investigate the pharmacological mechanisms involved in this action.
METHODS AND RESULTS:
The oral administration of (-)-alpha-Bisabolol 100 and 200 mg/kg was able to protect the gastric mucosa from ethanol (0.2 mL/animal p.o.) and indomethacin-induced ulcer (20 mg/kg p.o.). Administration of L-NAME (10 mg/kg i.p.), glibenclamide (10 mg/kg i.p.) or indomethacin (10 mg/kg p.o.) was not able to revert the gastroprotection promoted by (-)-alpha-Bisabolol 200 mg/kg on the ethanol-induced ulcer. Dosage of gastric reduced glutathione (GSH) levels showed that ethanol and indomethacin reduced the content of non-protein sulfhydryl (NP-SH) groups, while (-)-alpha-Bisabolol significantly decreased the reduction of these levels on ulcer-induced mice, but not in mice without ulcer.
CONCLUSIONS:
In conclusion, gastroprotective effect on ethanol and indomethacin-induced ulcer promoted by (-)-alpha-Bisabolol may be associated with an increase of gastric sulfydryl groups bioavailability leading to a reduction of gastric oxidative injury induced by ethanol and indomethacin.
