(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Eur J Pharmacol.2024, 975:176644.
Processes2021, 9(1), 153;
Microb Pathog.2024, 189:106609.
Nutrients.2023, 15(4):950.
Mol Nutr Food Res.2024, 68(20):e2400414.
Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
Progress In Microbes & Molecular Biology2025, 8,1:a0000470.
Plants (Basel).2021, 10(11):2525.
Food Science and Preservation2024, 31(3):486-498.
J Nat Med.2022, 76(1):59-67.
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Planta Medica, 2009, 75(4):401-402.
Evaluation of the Anti-inflammatory Potential of Chinese Botanicals[Reference:
WebLink]
Traditional Chinese medicine (TCM) has been using about 1300 plants for anti-inflammatory purposes.
METHODS AND RESULTS:
Activity guided isolation in a medium throughput approach has resulted in the discovery of a number of new drug leads. From the fruits of Evodia rutaecarpa (Juss.) Benth. (Rutaceae), several quinolinone alkaloids, like 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone((Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one ), 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evo-carpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone, have been isolated which showed strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes [1].
CONCLUSIONS:
They showed no cytotoxic activity and might bind to the lipid binding site of 5-LOX [2]. Moreover they were very effective against mycobacteria [3].
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