Product Name Xanthorin
CAS No.: 17526-15-7
Catalog No.: CFN99826
Molecular Formula: C16H12O6
Molecular Weight: 300.3 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Red powder
Source: The seeds of Cassia obtusifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Xanthorin has anticomplementary activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    To study the anti-complementary anthraquinones from Polygonum cuspidatum and their action targets.
    The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolates were evaluated for their in vitro anti-complementary activities. The action targets of the main bioactive constituents were also examined using complement-depleted sera. Ten anthraquinones and three other compounds were isolated from the EtOAc fraction of P.cuspidatum extract, including physcion(1), chrysophanol(2), questin(3), emodin-8-O-β-D-glucoside(4), emodin(5), rhein(6),fallacinol(7), citreorosein(8), Xanthorin(9), isorhodoptilometrin(10), 2, 5-dimethyl-7-hydroxychromone(11), 7-hydroxy-4-methoxy-5-methylcoumarin(12), and 5, 7-dihydroxy-1-isobenzofuranone(13). Compounds 9 and 10 were isolated from the the plants of Polygonaceae for the first time, and compound 9 was the alizarin-type anthraquinone first obtained from P. cuspidatum. Compounds3—9 showed the anti-complementary activity in different degrees, and compound 7 exhibited the most significant activity against the classical and alternative pathway [CH50=(6 ± 2) μg/mL, AP50=(50 ± 5) μg/mL]. The study on the preliminary mechanism revealed that compound 4 interacted with C1q, C2, and C9 in complement activation cascade, while compound 7 acted on C1q, C2, C4, and C9.
    The anthraquinones are main anti-complementary constituents in P. cuspidatum; and fallacinol(7) is a potential complement inhibitor with strong activity and definite targets, which should be further studied in future.
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