Vindesine
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41.
Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.[Pubmed:
22246157]
Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies.
METHODS AND RESULTS:
Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported.
CONCLUSIONS:
Alternative treatment containing Vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.
Leuk Res. 2009 Dec;33(12):e232-3.
Vindesine-induced neuropathy mimicking Guillain-Barré syndrome.[Pubmed:
19428104]
METHODS AND RESULTS:
A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including Vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome.
CONCLUSIONS:
Spinal fluid analysis showed a normal protein level, Vindesine neuropathy seemed to be the cause of the patient's neurological symptoms.The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.
