Vindesine

J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41.

Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.[Pubmed: 22246157]

Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies.
METHODS AND RESULTS:
Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported.
CONCLUSIONS:
Alternative treatment containing Vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.

Leuk Res. 2009 Dec;33(12):e232-3.

Vindesine-induced neuropathy mimicking Guillain-Barré syndrome.[Pubmed: 19428104]

METHODS AND RESULTS:
A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including Vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome.
CONCLUSIONS:
Spinal fluid analysis showed a normal protein level, Vindesine neuropathy seemed to be the cause of the patient's neurological symptoms.The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.