Vicenin -1

Vicenin -1
Product Name Vicenin -1
CAS No.: 35927-38-9
Catalog No.: CFN92030
Molecular Formula: C26H28O14
Molecular Weight: 564.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: Aldose reductase
Source: The herbs of Vitex negundo L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $268/20mg
Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • J Ethnopharmacol.2020, 260:112988.
  • Appl. Sci.2020, 10(5),1713.
  • Exp Parasitol.2015, 153:160-4
  • Heliyon.2024, 10(23):e40758.
  • National Academy Science Letters2023, s40009.
  • Cytotechnology.2017, 69(5):765-773
  • J Sci Food Agric.2023, 103(1):213-220.
  • Chem Biol Interact.2018, 283:59-74
  • Prev Nutr Food Sci.2024, 29(4):563-571.
  • Senecionine N-oxide

    Catalog No: CFN00418
    CAS No: 13268-67-2
    Price: $268/5mg
    Benzoylaconine

    Catalog No: CFN98577
    CAS No: 466-24-0
    Price: $238/20mg
    Limocitrin

    Catalog No: CFN92385
    CAS No: 489-33-8
    Price: Inquiry(manager@chemfaces.com)
    6-Shogaol

    Catalog No: CFN99531
    CAS No: 555-66-8
    Price: $118/20mg
    Rubiadin 1-methyl ether

    Catalog No: CFN97227
    CAS No: 7460-43-7
    Price: $268/10mg
    Journal of the Korean Society for Applied Biological Chemistry, 2015, 58(3):365-371.
    Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase.[Reference: WebLink]
    Saussurea grandifolia was tested for aldose reductase (AR) inhibition as part of a search for potentially therapeutic natural compounds.
    METHODS AND RESULTS:
    Stepwise polarity fractions were tested for in vitro inhibition of rat lens AR. Of these, the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions exhibited AR inhibitory activities. A chromatographic separation of the active EtOAc and n-BuOH fractions led to the isolation of nine compounds, which were known and identified as vitexin (1), genkwanin-5-O-glucoside (2), vitexin 2″-p-hydroxybenzoate (3), kaempferol-3-O-rutinoside (4), isovitexin (5), quercitrin (6), isoquercitrin (7), 1,5-di-O-caffeoylquinic acid (8), and Vicenin -1 (9). Among these compounds, compounds 6, 7, and 8 showed very strong inhibitory activities against AR (IC50’s = 0.34, 0.32, and 0.08 μM, respectively).
    CONCLUSIONS:
    The results suggest that S. grandifolia is clearly a potential source for therapeutic agent that might be useful for the treatment of diabetic complications.
    Regulatory Toxicology and Pharmacology, 2016:S0273230016303026.
    Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice.[Reference: WebLink]
    Vicenin -1 (fenugreek glycoside) has been proven to possess potent anti-inflammatory and anti-oxidant activity. The objective of the present investigation was to determine in-vivo acute and subacute (28-days repeated dose) oral toxicity of Vicenin -1 isolated from fenugreek seed.
    METHODS AND RESULTS:
    Vicenin-1 (93%) was isolated from a hydroalcoholic extract of fenugreek seed and characterized using HPLC, TLC, 1H NMR and 13C NMR. Acute oral toxicity (AOT) and subacute toxicity studies of Vicenin -1 were carried out according to OECD 425 (up-and-down procedure) and OCED 407 guidelines in Swiss albino mice. In AOT, Vicenin -1showed 10% mortality when administered at a dose of 5000 mg/kg. However, when vicenin-1 was administered for at doses of 37.5, 75, or 150 mg/kg 28-days it did not show any mortality at the administered doses. Vicenin -1 (75 mg/kg) did not show observational, behavioral, biochemical or histopathological toxic effects. There were minor alterations in body weight, hematology, and histopathology of mice administered with Vicenin -1 (150 mg/kg), but these changes were within normal laboratory ranges. The highest concentration of Venicin-1 was found in liver (3.46%) followed by lung (0.65%).
    CONCLUSIONS:
    In conclusion, Vicenin -1 showed median lethal dose (LD50) of 4837.5 mg/kg with no-observed-adverse-effect levels (NOAEL) at 75 mg/kg and lowest adverse effect levels (LOAEL) at 150 mg/kg for both sexes of mice during AOT and sub-acute toxicity study, respectively.
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

    Catalog No: CFN95140
    CAS No: 100667-52-5
    Price: $318/5mg
    Rhamnocitrin 3-apiosyl-(1->2)-glucoside

    Catalog No: CFN95145
    CAS No: 148031-68-9
    Price: $318/10mg
    Momordicine II

    Catalog No: CFN95167
    CAS No: 91590-75-9
    Price: $318/10mg
    Pterodonoic acid

    Catalog No: CFN95183
    CAS No: 62458-42-8
    Price: $413/5mg
    1,2-Epoxy-10(14)-furanogermacren-6-one

    Catalog No: CFN95214
    CAS No: 383368-24-9
    Price: $318/10mg
    Gypenoside XIII

    Catalog No: CFN95239
    CAS No: 80325-22-0
    Price: $288/10mg
    Euphorbia factor L24

    Catalog No: CFN95334
    CAS No: 1613700-13-2
    Price: $318/5mg
    Picraquassioside B

    Catalog No: CFN95378
    CAS No: 169312-05-4
    Price: $318/10mg
    Ganoderic acid beta

    Catalog No: CFN95537
    CAS No: 217476-76-1
    Price: $413/5mg